Human vWF is a serum glycoprotein that mediates platelet adhesion to injured vascular endothelium. vWF function is regulated by ADAMTS13 mediated proteolysis within the A2 domain. Mutations of this protease cause thrombotic thrombocytopenic purpura.
vWF-A2 Antibody (490628) [DyLight 350]
Novus Biologicals | Catalog # FAB27642D
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
DyLight 350 (Excitation = 353 nm, Emission = 432 nm)
Antibody Source
Monoclonal Mouse IgG1 Clone # 490628
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Product Specifications
Immunogen
KLH-conjugated human vWF synthetic peptide
Asp1596-Tyr1605
Accession # NP_000543
Asp1596-Tyr1605
Accession # NP_000543
Specificity
Detects human vWF‑A2 (ADAMTS13-cleaved) in Western blots. This antibody detects a nascent epitope that is generated upon cleavage of recombinant human (rh) vWF-A2 domain with ADAMTS13. It does not detect intact rhvWF-A2 domain.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Applications for vWF-A2 Antibody (490628) [DyLight 350]
Application
Recommended Usage
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: vWF-A2
Long Name
von Willebrand Factor A2 Domain
Alternate Names
F8VWF, vWFA2
Gene Symbol
VWF
Additional vWF-A2 Products
Product Documents for vWF-A2 Antibody (490628) [DyLight 350]
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for vWF-A2 Antibody (490628) [DyLight 350]
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Related Research Areas
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
- Cellular Response to Hypoxia Protocols
- R&D Systems Quality Control Western Blot Protocol
- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
- Western Blot Protocol for Cell Lysates
- Western Blot Troubleshooting
- Western Blot Troubleshooting Guide
- View all Protocols, Troubleshooting, Illustrated assays and Webinars
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Associated Pathways
