Catalog Number: 2652
Chemical Name: N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine
Biological Activity
Potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors.
Technical Data
  • M.Wt:
    415.19
  • Formula:
    C16H13BrF2N2O4
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    868359-05-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2.
    Dunlop et al.
    Mol.Pharmacol., 2005;68:974
  2. Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement.
    Beart and Shea
    Br.J.Pharmacol., 2007;150:5
Citations:

The citations listed below are publications that use Tocris products. Selected citations for WAY 213613 include:

1 Citations: Showing 1 - 1

  1. Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-α in cortical astrocytes from a rat model of amyotrophic lateral sclerosis.
    Authors: Dumont Et al.
    Evid Based Complement Alternat Med 2014;9:e97649

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