Potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50
values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors.
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All Tocris products are intended for laboratory research use only.
Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2.
Dunlop et al.
Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement.
Beart and Shea
The citations listed below are publications that use Tocris products. Selected citations for WAY 213613 include:
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