Chemical Name: N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine
Biological ActivityWAY 213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Complete Your Experiment
Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2.
Dunlop et al.
Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement.
Beart and Shea
Citations for WAY 213613
The citations listed below are publications that use Tocris products. Selected citations for WAY 213613 include:
3 Citations: Showing 1 - 3
Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model.
Authors: Falcucci Et al.
ACS Chem Neurosci 2019;10:3437
Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
Authors: Brancaccio Et al.
Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-α in cortical astrocytes from a rat model of amyotrophic lateral sclerosis.
Authors: Dumont Et al.
Evid Based Complement Alternat Med 2014;9:e97649
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for WAY 213613
There are currently no reviews for this product. Be the first to review WAY 213613 and earn rewards!
Have you used WAY 213613?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image