Wnt-C59

Catalog # Availability Size / Price Qty
5148/10
5148/50
Cat.No. 5148 - Wnt-C59 | C25H21N3O | CAS No. 1243243-89-1
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Description: Highly potent PORCN inhibitor

Chemical Name: 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide

Purity: ≥99%

Product Details
Citations (4)
Reviews

Biological Activity

Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable.

Technical Data

M.Wt:
379.45
Formula:
C25H21N3O
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1243243-89-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for Wnt-C59

The citations listed below are publications that use Tocris products. Selected citations for Wnt-C59 include:

4 Citations: Showing 1 - 4

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