Chemical Name: 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide
Biological ActivityHighly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Chemically defined generation of human cardiomyocytes.
Burridge et al.
Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.
Proffitt et al.
Cancer Res., 2013;73:502
WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer.
Wend et al.
EMBO Mol.Med., 2013;5:264
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.
Youssef et al.
Nat. Cell Biol., 2012;14:1282
Citations for Wnt-C59
The citations listed below are publications that use Tocris products. Selected citations for Wnt-C59 include:
14 Citations: Showing 1 - 10
A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees.
Authors: Ward and Gilad
Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells.
Authors: Liang Et al.
Stem Cells 2019;38:352
Capacitation of human na�ve pluripotent stem cells for multi-lineage differentiation.
Authors: Rostovskaya Et al.
Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES.
Authors: Pfeiffer Et al.
Nat Commun 2018;9:440
An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells.
Authors: Jiang Et al.
Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation.
Authors: Sharma Et al.
Sci Rep 2018;8:6618
A Comparative Assessment of Human and Chimpanzee iPSC-derived Cardiomyocytes with Primary Heart Tissues.
Authors: Pavlovic Et al.
Sci Rep 2018;8:15312
A promoter interaction map for cardiovascular disease genetics.
Authors: Montefiori Et al.
Human-Induced Pluripotent Stem Cells Manufactured Using a Current Good Manufacturing Practice-Compliant Process Differentiate Into Clinically Relevant Cells From Three Germ Layers.
Authors: Shafa Et al.
Front Med (Lausanne) 2018;5:69
Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function.
Authors: Hoes Et al.
Eur J Heart Fail 2018;20:910
Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling.
Authors: Piccini Et al.
Front Physiol 2017;8:705
Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells.
Authors: Marczenke Et al.
Front Physiol 2017;8:469
A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation.
Authors: Bernatik Et al.
Front Cell Dev Biol 2017;5:47
Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development.
Authors: Nigmatullina Et al.
EMBO J 2017;36:869
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