Wnt-C59

  ( 3 citations )    
Product Datasheet
Catalog Number:5148
Chemical Name:4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide
Product Details
Citations (3)
Reviews
Biological Activity
Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable.
Technical Data
  • M.Wt:
    379.45
  • Formula:
    C25H21N3O
  • Solubility:
    Soluble to 20 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    1243243-89-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Wnt-C59 include:

3 Citations: Showing 1 - 3
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  1. Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells.
    Authors: Marczenke Et al.
    Front Physiol  2017;8:469
  2. A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation.
    Authors: Bernatik Et al.
    Front Cell Dev Biol  2017;5:47
  3. Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development.
    Authors: Nigmatullina Et al.
    EMBO J  2017;36:869

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