Chemical Name: 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide
Biological ActivityHighly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Chemically defined generation of human cardiomyocytes.
Burridge et al.
Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.
Proffitt et al.
Cancer Res., 2013;73:502
WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer.
Wend et al.
EMBO Mol.Med., 2013;5:264
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.
Youssef et al.
Nat. Cell Biol., 2012;14:1282
Citations for Wnt-C59
The citations listed below are publications that use Tocris products. Selected citations for Wnt-C59 include:
4 Citations: Showing 1 - 4
Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling.
Authors: Piccini Et al.
Front Physiol 2017;8:705
Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells.
Authors: Marczenke Et al.
Front Physiol 2017;8:469
A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation.
Authors: Bernatik Et al.
Front Cell Dev Biol 2017;5:47
Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development.
Authors: Nigmatullina Et al.
EMBO J 2017;36:869
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