WWL 123

Catalog # Availability Size / Price Qty
5317/10
5317/50
Cat.No. 5317 - WWL 123 | C28H24N2O3 | CAS No. 1338574-83-6
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Description: α/β-hydrolase domain 6 (ABHD6) inhibitor; antiepileptic

Chemical Name: N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester

Purity: ≥98%

Product Details
Reviews

Biological Activity

α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 0.43 μM). Blocks PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Antiepileptic activity is independent of CB1 and CB2 receptors, but is GABAA receptor dependent. Brain penetrant.

Other Information

There appears to be some confusion about the structure of WWL 123. Tocris sells N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester [1338574-83-6], which has been confirmed by the inventor, Prof B. Cravatt, as the correct compound. Other vendors sell the corresponding 3-yl regioisomer [1338575-41-9], which is the incorrect compound.

Technical Data

M.Wt:
436.5
Formula:
C28H24N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1338574-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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