-hydrolase domain 6 (ABHD6) inhibitor (IC50
= 0.43 μ
M). Blocks PTZ
-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Antiepileptic activity is independent of CB1
receptors, but is GABAA
receptor dependent. Brain penetrant.
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ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.
Naydenov et al.