XL01126

Key Product Details

Product Description

XL01126 is a potent LRRK2 Degrader (PROTAC^®) effective in multiple cell lines (DC₅₀ values within 15-72 nM, Dmax values range from 82-90%). Exhibits high cell permeability and forms a positively cooperative ternary complex with VHL and LRRK2, which compensates for a substantial loss of binary binding affinities to VHL and LRRK2, increasing its degradation performance in cells. Orally bioavailable (F=15%), XL01126 can penetrate the blood brain barrier after oral and parenteral dosing in mice.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license

Licensing Information

Sold under licence from the University of Dundee

Product Specifications for XL01126

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for XL01126

The following data is based on the product molecular weight 1019.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.98 mL	4.90 mL	9.81 mL
5 mM	0.20 mL	0.98 mL	1.96 mL
10 mM	0.10 mL	0.49 mL	0.98 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Liu Discovery of XL01126: a potent, fast, cooperative, selective, orally bioavailable, and blood-brain barrier penetrant PROTAC degrader of leucine-rich repeat kinase 2. JACS 2022 PMID: 36007011

Product Documents for XL01126