XMD 8-92

Catalog # Availability Size / Price Qty
4132/10
4132/50
XMD 8-92 | CAS No. 1234480-50-2 | ERK Inhibitors
1 Image
Description: ERK5/BMK1 inhibitor; also BRD4 inhibitor

Chemical Name: 2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

ERK5 (BMK1) and BRD4 inhibitor (Kd values are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of XMD 8-92 is reviewed on the chemical probes website.

Technical Data

M.Wt:
474.55
Formula:
C26H30N6O3
Solubility:
Soluble to 40 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1234480-50-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the Dana-Farber Cancer Institute.

Product Datasheets

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Citations for XMD 8-92

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4 Citations: Showing 1 - 4

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