YM 58483

Catalog # Availability Size / Price Qty
3939/10
3939/50
Other Calcium Channel Inhibitors Small Molecule
1 Image
Description: Inhibitor of SOCE in non-excitable cells
Alternative Names: Btp2

Chemical Name: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.

Technical Data

M.Wt:
421.32
Formula:
C15H9F6N5OS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
223499-30-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes.
    Ishikawa et al.
    J.Immunol., 2003;170:4441
  2. Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.
    Zitt et al.
    J.Biol.Chem., 2004;26:12427
  3. Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo.
    Ohga et al.
    Int.Immunopharmocol., 2008;8:1787

Product Datasheets

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Citations for YM 58483

The citations listed below are publications that use Tocris products. Selected citations for YM 58483 include:

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Store-operated calcium entry blocker
By Anonymous on 01/31/2018
Species: Mouse

Used to block SOCE mechanism but no effect was seen. Unsure about efficacy of the compound, it might be a lack of SOCE involvement in the biological process studied here.


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