YM 58483

Biological Activity

Blocker of store-operated Ca²⁺ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca²⁺ influx (IC₅₀ = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca²⁺ influx and IL-2 production in T lymphocytes.
   Ishikawa et al.
   J.Immunol., 2003;170:4441
2. Potent inhibition of Ca²⁺ release-activated Ca²⁺ channels and T-lymphocyte activation by the pyrazole derivative BTP2.
   Zitt et al.
   J.Biol.Chem., 2004;26:12427
3. Characterization of YM-58483/BTP2, a novel store-operated Ca²⁺ entry blocker, on T cell-mediated immune responses in vivo.
   Ohga et al.
   Int.Immunopharmocol., 2008;8:1787

Product Datasheets