Chemical Name: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
Biological ActivityBlocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes.
Ishikawa et al.
Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.
Zitt et al.
Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo.
Ohga et al.
Citations for YM 58483
The citations listed below are publications that use Tocris products. Selected citations for YM 58483 include:
2 Citations: Showing 1 - 2
A store-operated calcium channel inhibitor attenuates collagen-induced arthritis.
Authors: Gao Et al.
Br J Pharmacol 2015;172:2991
Potent analgesic effects of a store-operated calcium channel inhibitor.
Authors: Gao Et al.
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Reviews for YM 58483
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Used to block SOCE mechanism but no effect was seen. Unsure about efficacy of the compound, it might be a lack of SOCE involvement in the biological process studied here.