YM 58483

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3939
Alternate Names:Btp2
Chemical Name:N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
Product Details
Citations (2)
Reviews
Biological Activity
Blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.
Technical Data
  • M.Wt:
    421.32
  • Formula:
    C15H9F6N5OS
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    223499-30-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for YM 58483 include:

2 Citations: Showing 1 - 2
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  1. A store-operated calcium channel inhibitor attenuates collagen-induced arthritis.
    Authors: Gao Et al.
    Br J Pharmacol  2015;172:2991
  2. Potent analgesic effects of a store-operated calcium channel inhibitor.
    Authors: Gao Et al.
    Pain  2013;154:2034

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Average Rating: 3 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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