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YM 58483

Catalog #: 3939
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3939/10
3939/50
YM 58483 | CAS No. 223499-30-7 | Other Calcium Channel Inhibitors
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Description: Inhibitor of SOCE in non-excitable cells
Alternative Names: Btp2

Chemical Name: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

YM 58483 is a blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.

Technical Data

M.Wt:
421.32
Formula:
C15H9F6N5OS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
223499-30-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for YM 58483

The citations listed below are publications that use Tocris products. Selected citations for YM 58483 include:

2 Citations: Showing 1 - 2

  1. A store-operated calcium channel inhibitor attenuates collagen-induced arthritis.
    Authors: Gao Et al.
    Br J Pharmacol  2015;172:2991
  2. Potent analgesic effects of a store-operated calcium channel inhibitor.
    Authors: Gao Et al.
    Pain  2013;154:2034

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