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Z-DEVD-FMK

2166 7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2166/1
Z-DEVD-FMK
1 Image
Description: Cell-permeable, irreversible caspase-3 inhibitor

Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone

Product Details
Citations (7)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.

Technical Data

M.Wt:
668.67
Formula:
C30H41FN4O12
Sequence:
DEVD

(Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)

Solubility:
Soluble to 13.37 mg/ml in DMSO
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Z-DEVD-FMK

The citations listed below are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:

7 Citations: Showing 1 - 7

  1. Lysosomotropism depends on glucose: a chloroquine resistance mechanism.
    Authors: Gallagher Et al.
    Cell Death Dis  2017;8:e3014
  2. Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning.
    Authors: Henson Et al.
    Neurobiol Learn Mem  2017;138:39
  3. Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
    Authors: Wu Et al.
    Nature Communications  2016;7:13150
  4. ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
    Authors: Bill Et al.
    BMB Rep  2015;6:9173
  5. The mTORC2 component rictor contributes to cisp. resistance in human ovarian cancer cells.
    Authors: Im-aram Et al.
    PLoS One  2013;8:e75455
  6. Hyperphosphorylation and cleavage at D421 enhance tau secretion.
    Authors: Plouffe Et al.
    PLoS One  2012;7:e36873
  7. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
    Authors: Woo Et al.
    J Biol Chem  2012;287:3963

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