Catalog Number: 2166
Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Biological Activity
Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)

  • Solubility:
    Soluble to 13.37 mg/ml in DMSO
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line.
    Brocksted et al.
    J.Biol.Chem., 1998;273:28057
  2. Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.
    Henshall et al.
    J.Neurochem., 2000;74:1215
  3. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway.
    Kugawa et al.
    Biol.Pharm.Bull., 2000;23:930
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