Z-DEVD-FMK: R&D Systems
Catalog Number: 2166
Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Biological Activity
Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)

  • Solubility:
    Soluble to 13.37 mg/ml in DMSO
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line.
    Brocksted et al.
    J.Biol.Chem., 1998;273:28057
  2. Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.
    Henshall et al.
    J.Neurochem., 2000;74:1215
  3. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway.
    Kugawa et al.
    Biol.Pharm.Bull., 2000;23:930

The citations listed below are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:

4 Citations: Showing 1 - 4
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  1. Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
    Authors: Wu Et al.
    Nature Communications 2016;7:13150
  2. ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
    Authors: Bill Et al.
    BMB Rep 2015;6:9173
  3. The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells.
    Authors: Im-aram Et al.
    PLoS One 2013;8:e75455
  4. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
    Authors: Woo Et al.
    J Biol Chem 2012;287:3963

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