Z-DEVD-FMK
Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Biological Activity
Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.Technical Data
(Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Casticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress.
Zhou Y, Tian L, Long L, Quan M, Liu F, Cao J
PLoS ONE, 2013;8(3):e58855. -
Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells.
Ham S, Kim K, Kwon T, Bak Y, Lee D, Song Y, Park S, Park Y, Kim M, Kang J, Hong J, Yoon D
Oncol Rep, 2014;31(6):2683-91. -
Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function.
Khoory J, Estanislau J, Elkhal A, Lazaar A, Melhorn M, Brodsky A, Illigens B, Hamachi I, Kurishita Y, Ivanov A, Shevkoplyas S, Shapiro N, Ghiran I
PLoS ONE, 2016;11(1):e0141206. -
Sensitization of multidrug-resistant cancer cells to Hsp90 inhibitors by NSAIDs-induced apoptotic and autophagic cell death
HJ Moon, HB Kim, SH Lee, SE Jeun, CD Kang, SH Kim
Oncotarget, 2018;9(13):11303-11321. -
Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line.
Brocksted et al.
J.Biol.Chem., 1998;273:28057 -
Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.
Henshall et al.
J.Neurochem., 2000;74:1215 -
Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway.
Kugawa et al.
Biol.Pharm.Bull., 2000;23:930
Product Datasheets
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Citations for Z-DEVD-FMK
The citations listed below are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:
8 Citations: Showing 1 - 8
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Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Authors: Rastogi Et al.
PLoS Pathog 2021;17:e1009712
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Lysosomotropism depends on glucose: a chloroquine resistance mechanism.
Authors: Gallagher Et al.
Cell Death Dis 2017;8:e3014
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Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning.
Authors: Henson Et al.
Neurobiol Learn Mem 2017;138:39
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Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
Authors: Wu Et al.
Nature Communications 2016;7:13150
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ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
Authors: Bill Et al.
BMB Rep 2015;6:9173
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The mTORC2 component rictor contributes to cisp. resistance in human ovarian cancer cells.
Authors: Im-aram Et al.
PLoS One 2013;8:e75455
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Hyperphosphorylation and cleavage at D421 enhance tau secretion.
Authors: Plouffe Et al.
PLoS One 2012;7:e36873
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Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
Authors: Woo Et al.
J Biol Chem 2012;287:3963
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