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Z-DEVD-FMK

  ( 5 citations )    
Product Datasheet
Catalog Number:2166
Chemical Name:Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Product Details
Citations (5)
Reviews
Biological Activity
Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.
Technical Data
  • M.Wt:
    668.67
  • Formula:
    C30H41FN4O12
  • Sequence:
    DEVD

    (Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)

  • Solubility:
    Soluble to 13.37 mg/ml in DMSO
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:

5 Citations: Showing 1 - 5
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  1. Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
    Authors: Wu Et al.
    Nature Communications  2016;7:13150
  2. ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
    Authors: Bill Et al.
    BMB Rep  2015;6:9173
  3. The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells.
    Authors: Im-aram Et al.
    PLoS One  2013;8:e75455
  4. Hyperphosphorylation and cleavage at D421 enhance tau secretion.
    Authors: Plouffe Et al.
    PLoS One  2012;7:e36873
  5. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
    Authors: Woo Et al.
    J Biol Chem  2012;287:3963

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