( 5 citations )    
Product Datasheet
Catalog Number:2166
Chemical Name:Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Product Details
Citations (5)
Biological Activity
Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)

  • Solubility:
    Soluble to 13.37 mg/ml in DMSO
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:

5 Citations: Showing 1 - 5
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  1. Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
    Authors: Wu Et al.
    Nature Communications  2016;7:13150
  2. ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
    Authors: Bill Et al.
    BMB Rep  2015;6:9173
  3. The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells.
    Authors: Im-aram Et al.
    PLoS One  2013;8:e75455
  4. Hyperphosphorylation and cleavage at D421 enhance tau secretion.
    Authors: Plouffe Et al.
    PLoS One  2012;7:e36873
  5. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
    Authors: Woo Et al.
    J Biol Chem  2012;287:3963


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