Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Biological ActivityZ-DEVD-FMK is a cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.
(Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line.
Brocksted et al.
Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.
Henshall et al.
Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway.
Kugawa et al.
Citations for Z-DEVD-FMK
The citations listed below are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:
8 Citations: Showing 1 - 8
Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Authors: Rastogi Et al.
PLoS Pathog 2021;17:e1009712
Lysosomotropism depends on glucose: a chloroquine resistance mechanism.
Authors: Gallagher Et al.
Cell Death Dis 2017;8:e3014
Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning.
Authors: Henson Et al.
Neurobiol Learn Mem 2017;138:39
Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
Authors: Wu Et al.
Nature Communications 2016;7:13150
ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
Authors: Bill Et al.
BMB Rep 2015;6:9173
The mTORC2 component rictor contributes to cisp. resistance in human ovarian cancer cells.
Authors: Im-aram Et al.
PLoS One 2013;8:e75455
Hyperphosphorylation and cleavage at D421 enhance tau secretion.
Authors: Plouffe Et al.
PLoS One 2012;7:e36873
Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
Authors: Woo Et al.
J Biol Chem 2012;287:3963
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