Home / Multidrug Transporter Inhibitors / Zosuquidar trihydrochloride

Zosuquidar trihydrochloride

Catalog #: 5456 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5456/10
5456/50
Zosuquidar trihydrochloride | CAS No. 167465-36-3 | Multidrug Transporter Inhibitors
1 Image
Description: High affinity P-gp inhibitor
Alternative Names: LY 335979

Chemical Name: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride

Purity: ≥97%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

Technical Data

M.Wt:
636.99
Formula:
C32H31F2N3O2.3HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
167465-36-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Complete Your Research

Selective inhibitor of SIRT2
Cat # 5457
High affinity C5a receptor antagonist
Cat # 5455
Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
Cat # 4447
Potent and selective Lck and Src inhibitor; also inhibits SIK
Cat # 5413
Selective high affinity CB2 agonist
Cat # 1038
Plasminogen activator inhibitor-1 (PAI-1) inhibitor
Cat # 5565
Negative control of SGC 707 (Cat. No. 5367)
Cat # 5450
Potent and selective 5-HT2A antagonist
Cat # 4173
Photoswitchable Kv channel blocker
Cat # 5462
Inhibits TCF/β-catenin-mediated transcription
Cat # 4505
Potent and selective breast tumor kinase (Brk) inhibitor
Cat # 5579
Selective Kir3.1/3.2 (GIRK1/2) channel activator
Cat # 5380
Selective blocker of inward-rectifier K+ channels
Cat # 1316

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Zosuquidar trihydrochloride

There are currently no reviews for this product. Be the first to review Zosuquidar trihydrochloride and earn rewards!

Have you used Zosuquidar trihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.