Zosuquidar trihydrochloride

Tocris Bioscience | Catalog # 5456

High affinity P-gp inhibitor
Tocris Bioscience
Discontinued Product
5456 has been discontinued. View all Multidrug Transporter Inhibitors products.

Key Product Details

Description

High affinity P-gp inhibitor

Alternative Names

LY 335979
View all Multidrug Transporter Inhibitors »

Product Description

Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

Product Specifications for Zosuquidar trihydrochloride

Molecular Weight

636.99

Formula

C32H31F2N3O2.3HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride

CAS Number

167465-36-3

PubChem ID

153997

InChI Key

ZPFVQKPWGDRLHL-ZLYBXYBFSA-N

SMILES

F[C@@]2(F)[C@H]1C3=C(C=CC=C3)[C@H](N5CCN(C[C@H](COC6=CC=CC7=C6C=CC=N7)O)CC5)C4=C(C=CC=C4)[C@H]12.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.85 50

Preparing Stock Solutions for Zosuquidar trihydrochloride

The following data is based on the product molecular weight 636.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.14 mL 15.70 mL 31.40 mL
2.5 mM 0.63 mL 3.14 mL 6.28 mL
5 mM 0.31 mL 1.57 mL 3.14 mL
25 mM 0.06 mL 0.31 mL 0.63 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for Zosuquidar trihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Zosuquidar trihydrochloride

For research use only

Citations for Zosuquidar trihydrochloride

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