Zosuquidar trihydrochloride

Catalog # Availability Size / Price Qty
5456/10
5456/50
Cat.No. 5456 - Zosuquidar trihydrochloride | C32H31F2N3O2.3HCl | CAS No. 167465-36-3
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Description: High affinity P-gp inhibitor
Alternative Names: LY 335979

Chemical Name: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride

Purity: ≥98%

Product Details
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Biological Activity

High affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

Technical Data

M.Wt:
636.99
Formula:
C32H31F2N3O2.3HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
167465-36-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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