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Zosuquidar trihydrochloride

5456 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5456/10
5456/50
Zosuquidar trihydrochloride | CAS No. 167465-36-3 | Multidrug Transporter Inhibitors
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Description: High affinity P-gp inhibitor
Alternative Names: LY 335979

Chemical Name: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride

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Biological Activity

High affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

Technical Data

Formula:
C32H31F2N3O2.3HCl
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
167465-36-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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