Show Categories

Mast Cell Markers

Click on one of the cell types shown in the buttons below to see the human and mouse markers commonly used to identify the different types of granulocytes.

Property title
Human
Human
Cell Surface Markers
Cell Surface Markers
Lin-
Lin-
CD11b/Integrin alpha M-
CD11b/Integrin alpha M-
CD11c-/low
CD11c-/low
ProductsClose
CD33/Siglec-3+
CD33/Siglec-3+
CD45+
CD45+
ProductsClose
CD117/c-kithigh
CD117/c-kithigh
ProductsClose
ENPP-3/CD203c+
ENPP-3/CD203c+
Fc gamma RII/CD32+
Fc gamma RII/CD32+
Fc epsilon RI alpha+
Fc epsilon RI alpha+
HLA-DR-/low
HLA-DR-/low
ProductsClose
IL-3 R alpha/CD123low/+
IL-3 R alpha/CD123low/+
Integrin alpha 2/CD49b-
Integrin alpha 2/CD49b-
Intracellular Markers
Intracellular Markers
MITF+
MITF+
ProductsClose
Mouse
Mouse
Cell Surface Markers
Cell Surface Markers
Lin-
Lin-
CD11b/Integrin alpha M-
CD11b/Integrin alpha M-
CD11c-/low
CD11c-/low
ProductsClose
CD34+
CD34+
ProductsClose
CD45+
CD45+
ProductsClose
CD117/c-kithigh
CD117/c-kithigh
ProductsClose
CD200R3+
CD200R3+
ProductsClose
We currently do not offer products for this molecule. Use our Product Suggestion form to enter a request. You will be notified once it becomes available.
ENPP-3/CD203c+
ENPP-3/CD203c+
Fc epsilon RI alpha+
Fc epsilon RI alpha+
IL-3 R alpha/CD123low/+
IL-3 R alpha/CD123low/+
Integrin alpha 2/CD49b-
Integrin alpha 2/CD49b-
Integrin beta 7low/+
Integrin beta 7low/+
MHC class II-/low
MHC class II-/low

Overview

Mast cells are bone marrow-derived leukocytes that are released into the circulation as immature cells, which migrate to peripheral tissues where they terminally differentiate. They are found primarily in tissues that interact with the external environment including the skin, lung, and gastrointestinal tract. Upon activation induced by IgE-Fc epsilon RI receptor cross-linking, mast cells release mediators such as histamine, heparin, prostaglandin D2, cysteinyl leukotrienes, chymase, tryptase, and cytokines that have a variety of functions including smooth muscle contraction, increased vascular permeability, mucus production, and immune cell recruitment. Although mast cells are involved in defending the host against pathogens and promoting wound healing, their activity has also been associated with severe allergic reactions, anaphylaxis, and several autoimmune diseases. Flow cytometry can be used to identify mast cells based on their high level expression of CD117/c-kit with variable side scatter, along with expression of IL-3 R alpha/CD123 and Fc epsilon RI. Additionally, mast cells express ENPP-3/CD203c, and CD200 R3 in mice, as well as, the transcription factor, MITF, and they lack expression of MHC class II. Like basophils, mast cells also display upregulated expression of ENPP-3/CD203c and CD63 following activation.