Additional PERK-related Compounds Small Molecules and Peptides

PKR-like ER kinase (PERK, EIF2AK3), EC 2.7.11.1, is a eukaryotic initiation factor 2α (elF2α) kinase that inhibits protein translation and is important in the endoplasmic reticulum (ER) stress response. PERK is localized to the ER and contains a stress-sensing domain that faces the ER lumen, a transmembrane segment, and a cytosolic kinase domain.

PERK plays an integral role in the unfolded protein response (UPR) and integrated stress response (ISR). The UPR and ISR are activated by a ...