Bromodomain Inhibitors

Bromodomain Structure and Function

Bromodomains are protein structures that bind to histone tails and act as epigenetic "readers". There are approximately 61 unique human Bromodomains that have been identified across 42 proteins, with diverse functions from the histone acetyltransferase (HAT) PCAF, which adds acetyl groups to lysine residues on histone tails, to the ATP-dependent helicase SNF2L2. Some bromodomain-containing proteins can contain two or more of these epigenetic "reader" domains.

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