Ca2+-Activated Potassium Channel Activators

There are 8 members of the K_Ca channel family, all of which are homo or heterotetramers of α-subunits, with either 6 or 7 transmembrane domains. Some family members also have associated regulatory subunits. K_Ca1.1 (BK), K_Ca2.x (SK) and K_Ca3.1 (IK) ion channels open in response to intracellular Ca²⁺ levels. Other K_Ca family members, K_Ca4.1, K_Ca4.2 (now known as K_Na1.1 and K_Na1.2) and K_Ca5.1 are grouped with K_Ca1.1 (BK) based on their structural similarities, however relatively little is ...