NS 309

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NS 309 | CAS No. 18711-16-5 | Ca2+-Activated Potassium Channel Activators
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Description: Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels

Chemical Name: 6,7-Dichloro-1H-indole-2,3-dione 3-oxime

Purity: ≥98%

Product Details
Citations (10)

Biological Activity

NS 309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NS 309

The citations listed below are publications that use Tocris products. Selected citations for NS 309 include:

10 Citations: Showing 1 - 10

  1. Methyl-Beta-Cyclodextrin Restores KIR Channel Function in Brain Endothelium of Female Alzheimer's Disease Mice.
    Authors: Erik J Et al.
    J Alzheimers Dis Rep  2021;5:693-703
  2. Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice.
    Authors: Brant E Et al.
    Elife  2021;10
  3. Brain endothelial cell TRPA1 channels initiate neurovascular coupling.
    Authors: Brant E Et al.
    Elife  2021;10
  4. Site-specific opening of the blood-brain barrier by extracellular histones.
    Authors: Sarah Y Et al.
    J Neuroinflammation  2020;17:281
  5. Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: Differential roles of G-protein-coupled receptors and K+ channels.
    Authors: Hakim Et al.
    Pharmacol Res Perspect  2018;6:e00391
  6. Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides.
    Authors: Zhang Et al.
    Neurochem Int  2015;1:e1500008
  7. In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.
    Authors: Hipólito Et al.
    Pain  2015;156:849
  8. Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions?.
    Authors: Wong Et al.
    Br J Pharmacol  2014;171:2751
  9. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.
    Authors: D'Alessandro Et al.
    Cell Death Dis  2013;4:e773
  10. Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in PilC-treated epileptic rats.
    Authors: Oliveira Et al.
    Brain Res  2010;1348:187


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