NS 309
Chemical Name: 6,7-Dichloro-1H-indole-2,3-dione 3-oxime
Purity: ≥98%
Biological Activity
NS 309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery.
Grgic et al.
Br.J.Pharmacol., 2009;157:509 -
Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).
Strobaek et al.
Biochim.Biophys.Acta, 2004;1665:1 -
Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells.
Morimura et al.
J.Pharm.Sci., 2006;100:237
Product Datasheets
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Citations for NS 309
The citations listed below are publications that use Tocris products. Selected citations for NS 309 include:
6 Citations: Showing 1 - 6
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Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: Differential roles of G-protein-coupled receptors and K+ channels.
Authors: Hakim Et al.
Pharmacol Res Perspect 2018;6:e00391
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Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides.
Authors: Zhang Et al.
Neurochem Int 2015;1:e1500008
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In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.
Authors: Hipólito Et al.
Pain 2015;156:849
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Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions?.
Authors: Wong Et al.
Br J Pharmacol 2014;171:2751
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KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.
Authors: D'Alessandro Et al.
Cell Death Dis 2013;4:e773
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Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in PilC-treated epileptic rats.
Authors: Oliveira Et al.
Brain Res 2010;1348:187
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NS 309 is a potent Kca channel activator. I worked with 10,20,30,40,50,80,100 micrograms dissolved in DMSO. The product worked nicely in experimental conditions and would suggest to others researching Kca channel activation.
