NS 309

Catalog # Availability Size / Price Qty
3895/10
3895/50
NS 309 | CAS No. 18711-16-5 | Ca2+-Activated Potassium Channel Activators
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Description: Positive modulator of KCa2 and KCa3.1 channels

Chemical Name: 6,7-Dichloro-1H-indole-2,3-dione 3-oxime

Purity: ≥98%

Product Details
Citations (6)
Reviews (1)

Biological Activity

Positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.

Technical Data

M.Wt:
231.04
Formula:
C8H4Cl2N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
18711-16-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery.
    Grgic et al.
    Br.J.Pharmacol., 2009;157:509
  2. Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).
    Strobaek et al.
    Biochim.Biophys.Acta, 2004;1665:1
  3. Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells.
    Morimura et al.
    J.Pharm.Sci., 2006;100:237

Product Datasheets

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Citations for NS 309

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Reviews for NS 309

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NS 309 worked nicely on experimental conditions
By Anonymous on 10/29/2018
Species: Human

NS 309 is a potent Kca channel activator. I worked with 10,20,30,40,50,80,100 micrograms dissolved in DMSO. The product worked nicely in experimental conditions and would suggest to others researching Kca channel activation.


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