Chemical Name: 6,7-Dichloro-1H-indole-2,3-dione 3-oxime
Biological ActivityNS 309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery.
Grgic et al.
Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).
Strobaek et al.
Citations for NS 309
The citations listed below are publications that use Tocris products. Selected citations for NS 309 include:
10 Citations: Showing 1 - 10
Methyl-Beta-Cyclodextrin Restores KIR Channel Function in Brain Endothelium of Female Alzheimer's Disease Mice.
Authors: Erik J Et al.
J Alzheimers Dis Rep 2021;5:693-703
Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice.
Authors: Brant E Et al.
Brain endothelial cell TRPA1 channels initiate neurovascular coupling.
Authors: Brant E Et al.
Site-specific opening of the blood-brain barrier by extracellular histones.
Authors: Sarah Y Et al.
J Neuroinflammation 2020;17:281
Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: Differential roles of G-protein-coupled receptors and K+ channels.
Authors: Hakim Et al.
Pharmacol Res Perspect 2018;6:e00391
Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides.
Authors: Zhang Et al.
Neurochem Int 2015;1:e1500008
In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.
Authors: Hipólito Et al.
Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions?.
Authors: Wong Et al.
Br J Pharmacol 2014;171:2751
KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.
Authors: D'Alessandro Et al.
Cell Death Dis 2013;4:e773
Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in PilC-treated epileptic rats.
Authors: Oliveira Et al.
Brain Res 2010;1348:187
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