Catalog Number: 3895
Chemical Name: 6,7-Dichloro-1H-indole-2,3-dione 3-oxime
Biological Activity
Positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
Technical Data
  • M.Wt:
    231.04
  • Formula:
    C8H4Cl2N2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    18711-16-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery.
    Grgic et al.
    Br.J.Pharmacol., 2009;157:509
  2. Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).
    Strobaek et al.
    Biochim.Biophys.Acta, 2004;1665:1
  3. Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells.
    Morimura et al.
    J.Pharm.Sci., 2006;100:237
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NS 309 include:

1 Citations: Showing 1 - 1

  1. Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides.
    Authors: Zhang Et al.
    Neurochem Int 2015;1:e1500008

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