Calcineurin: Products

Calcineurin, also called Protein Phosphatase 2B, PP2B, PPP2B, Protein Phosphatase 3, and PPP3, is an enzyme that dephosphorylates serine and threonine residues in proteins.

Calcineurin A, also known as PP2B and PPP3CA, is the 59 kDa catalytic subunit of the calcium/calmodulin-dependent protein phosphatase. When activated by calcium in the presence of the regulatory B subunit and calmodulin, Calcineurin A selectively removes phosphates from serine and threonine residues on target proteins. Although ubiquitously expressed, Calcineurin levels are highest in brain. Calcineurin function in brain is thought to play a role in the formation and retention of memories. Calcineurin activity is inhibited by the immunosuppressant drug Cyclosporine A bound to cyclophilins.

"Calcineurin" has 8 results in Products.
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Cyclosporin A

Calcineurin inhibitor

FK 506

Potent calcineurin inhibitor; immunosuppressant

NFAT Inhibitor

Inhibitor of calcineurin-mediated NFAT activation

DLDVPIPGRFDRRVS(PO3)VAAE Ser/Thr Phosphatase Substrate I

Substrate for Calcineurin, PP1, PP2A, PP2C, and Ser/Thr phosphatases

Calcineurin Autoinhibitory Peptide

Selective calcineurin inhibitor

INCA-6

Inhibitor of calcineurin-substrate association

Ascomycin

Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)
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