Biological ActivityCyclosporin A is an immunosuppressant; simultaneously binds calcineurin and cyclophilin and inhibits phosphatase activity of calcineurin (IC50 = 5 nM). Additionally inhibits formation and opening of the mitochondrial permeability transition pore (MPTP). Also inhibits coronavirus replication in vitro. Enhances lentirival transduction of bone marrow-derived CD34+ cells and is additive with Prostaglandin E2 (Cat. No. 2296).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells.
Yan et al.
Inhibition of the mitochondrial permeability transition pore by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.
Brookemeier and Pfeiffer
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.
Fruman et al.
Evidence that cyclosporin A and dexameth. inhibit allergic airway inflammation via suppression of interleukin-5 synthesis by T cells.
Nakata et al.
Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant Ex Vivo gene therapy settings.
Petrillo et al.
Cyclosporin A inhibits the replication of diverse coronaviruses.
de Wilde et al.
MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment.
de Wilde et al.
Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir.
Carbajo-Lozoya et al.
Virus Res., 2014;184:44
Citations for Cyclosporin A
The citations listed below are publications that use Tocris products. Selected citations for Cyclosporin A include:
25 Citations: Showing 1 - 10
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Authors: Lopez Et al.
Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening.
Authors: Bhosale and Duchen
Curr Protoc Pharmacol 2019;:e59
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Authors: Panja Et al.
Neuropathol Appl Neurobiol 2019;45:141
High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
Authors: Battefeld Et al.
Cell Rep 2019;26:182
Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts.
Authors: Puri Et al.
Nat Commun 2019;10:3645
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease.
Authors: P?rez Et al.
Redox Biol 2018;19:290
Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
Authors: Burdyga Et al.
Proc Natl Acad Sci U S A. 2018;115(28):E6497
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
Authors: Agarwal Et al.
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Authors: Cui Et al.
Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
Authors: O'Donnell Et al.
J Neurosci 2016;36:7109
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
Authors: Miyamoto Et al.
Cardiorenal Med 2016;291:1719
A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030.
Authors: Palmqvist Et al.
J Inflamm (Lond) 2016;13:20
Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment.
Authors: Liu Et al.
Exp Eye Res 2015;5:79
Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via iverm. induces a non-apoptotic and inflammatory form of cancer cell death.
Authors: Draganov Et al.
J Neurosci 2015;5:16222
Neurotensin Induces Presynaptic Depression of D2 DA Autoreceptor-Mediated Neurotransmission in Midbrain DArgic Neurons.
Authors: Piccart Et al.
J Neurosci 2015;35:11144
NFATc1 activity regulates the expression of myocilin induced by dexameth.
Authors: Faralli Et al.
J Biol Chem 2015;130:42614
Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
Authors: Yu Et al.
PLoS One 2014;9:e112989
Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
Authors: Gray Et al.
Mol Immunol 2014;289:14600
Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
Authors: Gross Et al.
J Mol Cell Cardiol 2013;59:20
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
Authors: Pont Et al.
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
Authors: Li and Burrell
Learn Mem 2011;18:545
Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus.
Authors: George Et al.
J Neurophysiol 2011;106:319
Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization.
Authors: Ceglia Et al.
J Neurochem 2010;114:182
FcεRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.
Authors: Grodzki Et al.
PLoS One 2009;46:2539
A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation.
Authors: Belmeguenai and Hansel
J Biol Chem 2005;25:10768
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