Cyclosporin A

Tocris Bioscience | Catalog # 1101

Calcineurin inhibitor
Tocris Bioscience

Key Product Details

Description

Calcineurin inhibitor

Alternative Names

Ciclosporin A
View all Protein Ser/Thr Phosphatase Inhibitors »

Product Description

Cyclosporin A is an immunosuppressant; simultaneously binds calcineurin and cyclophilin and inhibits phosphatase activity of calcineurin (IC50 = 5 nM). Additionally inhibits formation and opening of the mitochondrial permeability transition pore (MPTP). Also inhibits coronavirus replication in vitro. Enhances lentirival transduction of bone marrow-derived CD34+ cells and is additive with Prostaglandin E2 (Cat. No. 2296).

Product Specifications for Cyclosporin A

Molecular Weight

1202.63

Formula

C62H111N11O12

Storage

Store at -20°C

Purity

≥98% (HPLC)

CAS Number

59865-13-3

PubChem ID

2909

InChI Key

PMATZTZNYRCHOR-CGLBZJNRSA-N

SMILES

[H][C@@]1(C(C)C)NC([C@@H](N(C(CN(C([C@@H](NC([C@]([C@@H]([C@@H](C/C=C/C)C)O)(N(C([C@](C(C)C)(N(C([C@@H](N(C([C@](CC(C)C)(N(C([C@H](NC([C@@H](NC([C@@H](N(C1=O)C)CC(C)C)=O)C)=O)C)=O)C)[H])=O)C)CC(C)C)=O)C)[H])=O)C)[H])=O)CC)=O)C)=O)C)CC(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 120.26 100
Ethanol 60.13 50

Preparing Stock Solutions for Cyclosporin A

The following data is based on the product molecular weight 1202.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.17 mL 0.83 mL 1.66 mL
10 mM 0.08 mL 0.42 mL 0.83 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 115 publications citing the usage of this product.

Product Documents for Cyclosporin A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cyclosporin A

For research use only

Related Research Areas

Epigenetics
Phosphatases and Regulators

Customer Reviews for Cyclosporin A (1)

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  • Cyclosporin against synthetic immunosuppressant
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/06/2019
    Used cyclosporin as a natural control to understand few other synthetic immunosuppressants.

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