Cyclosporin A

Catalog # Availability Size / Price Qty
1101/100
Protein Ser/Thr Phosphatase Inhibitors Small Molecule
1 Image
Description: Calcineurin inhibitor
Alternative Names: Ciclosporin A

Purity: ≥99%

Product Details
Citations (21)
Reviews (1)

Biological Activity

Immunosuppressant; inhibits phosphatase activity of calcineurin (IC50 = 5 nM). Also inhibits formation and opening of the mitochondrial permeability transition pore (MPTP).

Technical Data

M.Wt:
1202.63
Formula:
C62H111N11O12
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at -20°C
CAS No:
59865-13-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Cyclosporin A

The citations listed below are publications that use Tocris products. Selected citations for Cyclosporin A include:

21 Citations: Showing 1 - 10

  1. High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
    Authors: Battefeld Et al.
    Cell Rep  2019;26:182
  2. Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease.
    Authors: P?rez Et al.
    Redox Biol  2018;19:290
  3. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
    Authors: Burdyga Et al.
    Proc Natl Acad Sci U S A.  2018;115(28):E6497
  4. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
    Authors: Agarwal Et al.
    Neuron  2017;93:587
  5. Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
    Authors: Cui Et al.
    Elife  2016;5:e13185
  6. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
    Authors: O'Donnell Et al.
    J Neurosci  2016;36:7109
  7. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
    Authors: Miyamoto Et al.
    Cardiorenal Med  2016;291:1719
  8. A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030.
    Authors: Palmqvist Et al.
    J Inflamm (Lond)  2016;13:20
  9. Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment.
    Authors: Liu Et al.
    Exp Eye Res  2015;5:79
  10. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via iverm. induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    J Neurosci  2015;5:16222
  11. Neurotensin Induces Presynaptic Depression of D2 DA Autoreceptor-Mediated Neurotransmission in Midbrain DArgic Neurons.
    Authors: Piccart Et al.
    J Neurosci  2015;35:11144
  12. NFATc1 activity regulates the expression of myocilin induced by dexameth.
    Authors: Faralli Et al.
    J Biol Chem  2015;130:42614
  13. Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
    Authors: Yu Et al.
    PLoS One  2014;9:e112989
  14. Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
    Authors: Gray Et al.
    Mol Immunol  2014;289:14600
  15. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
    Authors: Gross Et al.
    J Mol Cell Cardiol  2013;59:20
  16. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
    Authors: Pont Et al.
    Mol.Endocrinol.  2012;26:1743
  17. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem  2011;18:545
  18. Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus.
    Authors: George Et al.
    J Neurophysiol  2011;106:319
  19. Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization.
    Authors: Ceglia Et al.
    J Neurochem  2010;114:182
  20. FcεRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.
    Authors: Grodzki Et al.
    PLoS One  2009;46:2539
  21. A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation.
    Authors: Belmeguenai and Hansel
    J Biol Chem  2005;25:10768

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Cyclosporin against synthetic immunosuppressant
By Anonymous on 02/06/2019
Species: Human

Used cyclosporin as a natural control to understand few other synthetic immunosuppressants.


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