Immunosuppressant; inhibits phosphatase activity of calcineurin (IC
= 5 nM). Also inhibits formation and opening of the mitochondrial permeability transition pore (MPTP).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Inhibition of the mitochondrial permeability transition pore by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.
Brookemeier and Pfeiffer
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.
Fruman et al.
Evidence that cyclosporin A and dexamethasone inhibit allergic airway inflammation via suppression of interleukin-5 synthesis by T cells.
Nakata et al.
Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells.
Yan et al.
The citations listed below are publications that use Tocris products. Selected citations for Cyclosporin A include:
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