Biological ActivityImmunosuppressant; inhibits phosphatase activity of calcineurin (IC50 = 5 nM). Also inhibits formation and opening of the mitochondrial permeability transition pore (MPTP).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells.
Yan et al.
Inhibition of the mitochondrial permeability transition pore by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.
Brookemeier and Pfeiffer
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.
Fruman et al.
Evidence that cyclosporin A and dexameth. inhibit allergic airway inflammation via suppression of interleukin-5 synthesis by T cells.
Nakata et al.
Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant Ex Vivo gene therapy settings.
Petrillo et al.
Citations for Cyclosporin A
The citations listed below are publications that use Tocris products. Selected citations for Cyclosporin A include:
21 Citations: Showing 1 - 10
High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
Authors: Battefeld Et al.
Cell Rep 2019;26:182
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease.
Authors: P?rez Et al.
Redox Biol 2018;19:290
Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
Authors: Burdyga Et al.
Proc Natl Acad Sci U S A. 2018;115(28):E6497
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
Authors: Agarwal Et al.
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Authors: Cui Et al.
Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
Authors: O'Donnell Et al.
J Neurosci 2016;36:7109
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
Authors: Miyamoto Et al.
Cardiorenal Med 2016;291:1719
A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030.
Authors: Palmqvist Et al.
J Inflamm (Lond) 2016;13:20
Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment.
Authors: Liu Et al.
Exp Eye Res 2015;5:79
Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via iverm. induces a non-apoptotic and inflammatory form of cancer cell death.
Authors: Draganov Et al.
J Neurosci 2015;5:16222
Neurotensin Induces Presynaptic Depression of D2 DA Autoreceptor-Mediated Neurotransmission in Midbrain DArgic Neurons.
Authors: Piccart Et al.
J Neurosci 2015;35:11144
NFATc1 activity regulates the expression of myocilin induced by dexameth.
Authors: Faralli Et al.
J Biol Chem 2015;130:42614
Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
Authors: Yu Et al.
PLoS One 2014;9:e112989
Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
Authors: Gray Et al.
Mol Immunol 2014;289:14600
Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
Authors: Gross Et al.
J Mol Cell Cardiol 2013;59:20
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
Authors: Pont Et al.
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
Authors: Li and Burrell
Learn Mem 2011;18:545
Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus.
Authors: George Et al.
J Neurophysiol 2011;106:319
Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization.
Authors: Ceglia Et al.
J Neurochem 2010;114:182
FcεRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.
Authors: Grodzki Et al.
PLoS One 2009;46:2539
A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation.
Authors: Belmeguenai and Hansel
J Biol Chem 2005;25:10768
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Cyclosporin A
Average Rating: 4 (Based on 1 Review)
Have you used Cyclosporin A?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Used cyclosporin as a natural control to understand few other synthetic immunosuppressants.