Cyclosporin A

Catalog # Availability Size / Price Qty
Cyclosporin A | CAS No. 59865-13-3 | Protein Ser/Thr Phosphatase Inhibitors
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Description: Calcineurin inhibitor
Alternative Names: Ciclosporin A

Purity: ≥99%

Product Details
Citations (25)

Biological Activity

Cyclosporin A is an immunosuppressant; simultaneously binds calcineurin and cyclophilin and inhibits phosphatase activity of calcineurin (IC50 = 5 nM). Additionally inhibits formation and opening of the mitochondrial permeability transition pore (MPTP). Also inhibits coronavirus replication in vitro. Enhances lentirival transduction of bone marrow-derived CD34+ cells and is additive with Prostaglandin E2 (Cat. No. 2296).

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-beta-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
    Miyamoto T, Kim D, Knox J, Johnson E, Mucke L
    J Biol Chem, 2016;291(4):1719-34.
  2. APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway
    SG Cho
    Oncol Lett, 2017;14(4):4845-4852.
  3. ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis.
    Moguche A, Shafiani S, Clemons C, Larson R, Dinh C, Higdon L, Cambier C, Sissons J, Gallegos A, Fink P, Urdahl K
    J Exp Med, 2015;212(5):715-28.
  4. Autocrine Adenosine regulates tumor polyfunctional CD73+CD4+ effector T cells devoid of immune checkpoints
    N Gourdin, M Bossennec, C Rodriguez, S Vigano, C Machon, C Jandus, D Bauché, J Faget, I Durand, N Chopin, O Tredan, JC Marie, B Dubois, J Guitton, P Romero, C Caux, C Ménétrier-
    Cancer Res., 2018;0(0):.
  5. Studying mitochondrial Ca(2+) uptake - a revisit.
    Jean-Quartier C, Bondarenko AI, Alam MR
    Mol. Cell. Endocrinol., 2012;353(1):114-27.
  6. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  7. SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death
    Y Yue, NR Nabar, CS Shi, O Kamenyeva, X Xiao, IY Hwang, M Wang, JH Kehrl
    Cell Death Dis, 2018;9(9):904.
  8. Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells.
    Yan et al.
    BiochemsBiophys.Res.Commun., 2009;379:115
  9. Inhibition of the mitochondrial permeability transition pore by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.
    Brookemeier and Pfeiffer
    Biochemistry, 1995;34:16440
  10. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.
    Fruman et al.
    Proc.Natl.Acad.Sci.U.S.A., 1992;89:3686
  11. Evidence that cyclosporin A and dexameth. inhibit allergic airway inflammation via suppression of interleukin-5 synthesis by T cells.
    Nakata et al.
    Br.J.Pharmacol., 1998;124:1425
  12. Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant Ex Vivo gene therapy settings.
    Petrillo et al.
    Hum.Gene.Ther., 2019;
  13. Cyclosporin A inhibits the replication of diverse coronaviruses.
    de Wilde et al.
    J.Gen.Virol., 2011;92:2542
  14. MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment.
    de Wilde et al.
    J.Gen.Virol., 2013;94:1749
  15. Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir.
    Carbajo-Lozoya et al.
    Virus Res., 2014;184:44

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Citations for Cyclosporin A

The citations listed below are publications that use Tocris products. Selected citations for Cyclosporin A include:

25 Citations: Showing 1 - 10

  1. Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
    Authors: Lopez Et al.
    Neuron  2022;110:2283
  2. Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening.
    Authors: Bhosale and Duchen
    Curr Protoc Pharmacol  2019;:e59
  3. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
    Authors: Panja Et al.
    Neuropathol Appl Neurobiol  2019;45:141
  4. High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
    Authors: Battefeld Et al.
    Cell Rep  2019;26:182
  5. Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts.
    Authors: Puri Et al.
    Nat Commun  2019;10:3645
  6. Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease.
    Authors: P?rez Et al.
    Redox Biol  2018;19:290
  7. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
    Authors: Burdyga Et al.
    Proc Natl Acad Sci U S A.  2018;115(28):E6497
  8. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
    Authors: Agarwal Et al.
    Neuron  2017;93:587
  9. Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
    Authors: Cui Et al.
    Elife  2016;5:e13185
  10. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
    Authors: O'Donnell Et al.
    J Neurosci  2016;36:7109
  11. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
    Authors: Miyamoto Et al.
    Cardiorenal Med  2016;291:1719
  12. A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030.
    Authors: Palmqvist Et al.
    J Inflamm (Lond)  2016;13:20
  13. Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment.
    Authors: Liu Et al.
    Exp Eye Res  2015;5:79
  14. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via iverm. induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    J Neurosci  2015;5:16222
  15. Neurotensin Induces Presynaptic Depression of D2 DA Autoreceptor-Mediated Neurotransmission in Midbrain DArgic Neurons.
    Authors: Piccart Et al.
    J Neurosci  2015;35:11144
  16. NFATc1 activity regulates the expression of myocilin induced by dexameth.
    Authors: Faralli Et al.
    J Biol Chem  2015;130:42614
  17. Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
    Authors: Yu Et al.
    PLoS One  2014;9:e112989
  18. Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
    Authors: Gray Et al.
    Mol Immunol  2014;289:14600
  19. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
    Authors: Gross Et al.
    J Mol Cell Cardiol  2013;59:20
  20. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
    Authors: Pont Et al.
    Mol.Endocrinol.  2012;26:1743
  21. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem  2011;18:545
  22. Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus.
    Authors: George Et al.
    J Neurophysiol  2011;106:319
  23. Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization.
    Authors: Ceglia Et al.
    J Neurochem  2010;114:182
  24. FcεRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.
    Authors: Grodzki Et al.
    PLoS One  2009;46:2539
  25. A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation.
    Authors: Belmeguenai and Hansel
    J Biol Chem  2005;25:10768


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