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Calcium-activated Chloride Channel Activators Small Molecules and Peptides

Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin. TMEM16 (anoctamin) genes have been identified as pore-forming subunits for the channel.

CaCC have a variety of roles: in transepithelial salt transport; excitability in neurons, skeletal, cardiac and smooth muscle cells; acidification; cell cycle; oocyte fertilization; and ...

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Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A)

Chemical Name: 3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide
Purity: ≥98%
Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A)
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