DYRK Inhibitors

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are a family of serine/threonine kinases, consisting of DYRK1A, DYRK1B, DYRK2, DYRK3 and DYRK4. The DYRK family is closely related to the CMGC group of kinases (which contains CDKs, MAPKs, GSK and CLKs).

DYRKs are self-activated through auto phosphorylation of tyr-321 within the activation loop of their catalytic domain. Once activated, DYRKs phosphorylate serine and threonine residues on target proteins, which have been ...