10 results for "DYRK Inhibitors" in Products

DYRK Inhibitors

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are a family of serine/threonine kinases, consisting of DYRK1A, DYRK1B, DYRK2, DYRK3 and DYRK4. The DYRK family is closely related to the CMGC group of kinases (which contains CDKs, MAPKs, GSK and CLKs).

DYRKs are self-activated through auto phosphorylation of tyr-321 within the activation loop of their catalytic domain. Once activated, DYRKs phosphorylate serine and threonine residues on target proteins, which have been ...

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DYRK1A/B inhibitor

Chemical Name: (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
Purity: ≥98%
DYRK1A/B inhibitor
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Potent and selective DYRK1A inhibitor

Chemical Name: 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
Purity: ≥98%
Potent and selective DYRK1A inhibitor
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Potent and selective DYRK1A/B inhibitor

Alternate Names: R05454948
Chemical Name: N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Purity: ≥98%
Potent and selective DYRK1A/B inhibitor
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Potent DYRK1B inhibitor

Chemical Name: N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
Purity: ≥98%
Potent DYRK1B inhibitor
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Potent and selective Dyrk1B kinase inhibitor

Chemical Name: 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
Purity: ≥98%
Potent and selective Dyrk1B kinase inhibitor
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Inhibitor of Clk and DYRK kinases

Chemical Name: 5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride
Purity: ≥98%
Inhibitor of Clk and DYRK kinases
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Potent and selective DYRK inhibitor; orally bioavailable.

Chemical Name: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
Purity: ≥95%
Potent and selective DYRK inhibitor; orally bioavailable.
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Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2

Chemical Name: N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide
Purity: ≥98%
Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2
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Potent LMTK3 inhibitor

Chemical Name: 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Purity: ≥98%
Potent LMTK3 inhibitor
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Potent and selective pan-CLK inhibitor; also inhibits DYRK1A/B

Chemical Name: 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
Purity: ≥98%
Potent and selective pan-CLK inhibitor; also inhibits DYRK1A/B
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