8 results for "egf-receptor-degraders&view=expanded" in Products

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HER2 PROTAC® CH7C4

Catalog #: 7886
Citations (1)
Product Documents

Potent and selective HER2 targeting Degrader (PROTAC®)

Chemical Name: 5-((7-(4-(3-((4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperazin-1-yl)heptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity: ≥98%
Potent and selective HER2 targeting PROTAC®

Gefitinib-based PROTAC® 3

Catalog #: 7258
(1)
Citations (1)
Product Documents

Potent EGFR PROTAC® Degrader

Alternate Names: Iressa-based PROTAC 3
Chemical Name: (2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Potent EGFR PROTAC®

SJF 1521

Catalog #: 7261
Citations (1)
Product Documents

Selective EGFR PROTAC® Degrader

Chemical Name: (2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Selective EGFR PROTAC®

SJF 1528

Catalog #: 7262
Citations (1)
Product Documents

Potent EGFR PROTAC® Degrader; also degrades HER2

Chemical Name: (2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Potent EGFR PROTAC®; also degrades HER2

MS 154

Catalog #: 7395
Product Documents

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Chemical Name: 3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
Purity: ≥98%
Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

MS 39

Catalog #: 7397
Citations (1)
Product Documents

Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR

Chemical Name: (2S,4R)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR

MS 154N

Catalog #: 7396
Product Documents

Negative control for MS 154 (Cat No. 7395)

Chemical Name: 3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
Purity: ≥98%
Negative control for MS 154 (Cat No. 7395)

MS 39N

Catalog #: 7398
Product Documents

Negative control for MS 39 (Cat. No. 7397)

Chemical Name: (2R,4S)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Negative control for MS 39 (Cat. No. 7397)
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