Epithelial Sodium Channels (ENaC) Blockers

Epithelial sodium channels (ENaCs) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels. They are highly selective Na⁺ channels that are localized to polarized epithelial cells. ENaCs are responsible for sodium reabsorption in the distal kidney tubule, and have similar functions in the alveoli and the colon. These channels transport Na⁺ across the epithelium using energy from Na⁺, K⁺-ATPase, and constitute one of the essential mechanisms ...