3 results for "Glucagon-Like Peptide 1 Receptor Modulators Small Molecules and Peptides" in Products
Glucagon-Like Peptide 1 Receptor Modulators Small Molecules and Peptides
Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally (hypothalamus and brainstem) and peripherally (pancreatic islet cells, stomach and heart).
GLP-1 receptors mediate the effects of the incretin axis; the functional connection between the intestine and the islets of Langerhans in the pancreas. Activation stimulates insulin release from the islet β-cells in a glucose-dependent manner and suppresses glucagon secretion from islet α-cells. In addition, GLP-1 receptors delay gastric emptying and regulate appetite. The human GLP-1 receptor gene is localized on chromosome 6p21.
Positive allosteric modulator of GLP-1 receptors
| Chemical Name: | 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine |
| Purity: | ≥98% |
Negative allosteric modulator of glucagon and GLP-1 receptors
| Chemical Name: | 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide |
| Purity: | ≥98% |
Glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator
| Chemical Name: | (R)-2-(2-(1-((R)-1-(2,6-Dichloro-3-cyclopropylphenyl)ethyl)-1H-imidazo[4,5-c]pyridin-6-yl)phenyl)propanoic acid |
| Purity: | ≥98% |
