GPR35 Agonists

GPR35 is a Class A, rhodopsin-like G protein-coupled receptor which is predominantly expressed in immune and gastrointestinal tissue, with notable expression in the ileum (rat and human GPR35), the spleen (rat and murine GPR35) and the pancreas (human GPR35). Despite being first identified in 1998, the receptor is relatively poorly characterized and until recently was regarded as an orphan receptor. More recent work has identified kynurenic acid and lysophosphatidic acid as potential endogenous ...