Kynurenic acid

Catalog # Availability Size / Price Qty
0223/1G
Kynurenic acid | CAS No. 492-27-3 | iGluR Antagonists
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Description: Broad spectrum glutamatergic antagonist

Chemical Name: 4-Hydroxyquinoline-2-carboxylic acid

Purity: ≥98%

Product Details
Citations (15)
Supplemental Products
Reviews

Biological Activity

Kynurenic acid is a broad spectrum EAA antagonist. Putative GPR35 ligand.

Sodium Salt also available.

Technical Data

M.Wt:
189.17
Formula:
C10H7NO3
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at RT
CAS No:
492-27-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for Kynurenic acid

The citations listed below are publications that use Tocris products. Selected citations for Kynurenic acid include:

15 Citations: Showing 1 - 10

  1. Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
    Authors: Styr Et al.
    Neuron  2019;102:1009
  2. Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced mor. analgesia in a mouse neuropathic pain model.
    Authors: Rojewska Et al.
    Pharmacol Rep  2018;71:139
  3. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    Proc Natl Acad Sci U S A  2016;36:607
  4. Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.
    Authors: Weston Et al.
    Front Mol Neurosci  2014;7:1
  5. Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.
    Authors: Carver Et al.
    J Neurosci  2014;34:14181
  6. Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.
    Authors: Wu Et al.
    J Pharmacol Exp Ther  2013;346:146
  7. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
    Authors: Chen Et al.
    Neuron  2013;33:8336
  8. On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
    Authors: Gouet Et al.
    PLoS One  2012;7:e49293
  9. Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission.
    Authors: Weston Et al.
    J Neurosci  2012;32:11441
  10. Suppression of PKR promotes network excitability and enhanced cognition by IF.-γ-mediated disinhibition.
    Authors: Zhu Et al.
    Cell  2011;147:1384

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