Kynurenic acid

  ( 12 citations )    
Product Datasheet
Catalog Number:0223
Chemical Name:4-Hydroxyquinoline-2-carboxylic acid
Product Details
Citations (12)
Supplemental Products
Reviews
Biological Activity
Broad spectrum EAA antagonist. Putative GPR35 ligand.

Sodium Salt also available.

Technical Data
  • M.Wt:
    189.17
  • Formula:
    C10H7NO3
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in 1eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    492-27-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Kynurenic acid include:

12 Citations: Showing 1 - 10
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  1. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    Proc Natl Acad Sci U S A  2016;36:607
  2. Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.
    Authors: Weston Et al.
    Front Mol Neurosci  2014;7:1
  3. Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.
    Authors: Carver Et al.
    J Neurosci  2014;34:14181
  4. Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.
    Authors: Wu Et al.
    J Pharmacol Exp Ther  2013;346:146
  5. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
    Authors: Chen Et al.
    Neuron  2013;33:8336
  6. On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
    Authors: Gouet Et al.
    PLoS One  2012;7:e49293
  7. Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission.
    Authors: Weston Et al.
    J Neurosci  2012;32:11441
  8. Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition.
    Authors: Zhu Et al.
    Cell  2011;147:1384
  9. Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network.
    Authors: Shinoda Et al.
    Eur J Neurosci  2011;108:373
  10. Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons.
    Authors: Jones Et al.
    Int J Neuropsychopharmacol  2011;105:1984
  11. Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor.
    Authors: Young and Neher
    J Neurosci  2009;63:482
  12. Synaptic inputs to retinal ganglion cells that set the circadian clock.
    Authors: Perez-Leon Et al.
    J Neurophysiol  2006;24:1117
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