Chemical Name: 4-Hydroxyquinoline-2-carboxylic acid
Biological ActivityKynurenic acid is a broad spectrum EAA antagonist. Putative GPR35 ligand.
Sodium Salt also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35.
Wang J, Simonavicius N, Wu X et al.
J Biol Chem.
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.
Perkins and Stone
Brain Res., 1982;247:184
NMDA receptors and ligands in the vertebrate CNS.
Stone and Burton
The 'kynurenate test,' a biochemical assay for putative cognition enhancers.
Pittaluga et al.
Citations for Kynurenic acid
The citations listed below are publications that use Tocris products. Selected citations for Kynurenic acid include:
15 Citations: Showing 1 - 10
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
Authors: Styr Et al.
Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced mor. analgesia in a mouse neuropathic pain model.
Authors: Rojewska Et al.
Pharmacol Rep 2018;71:139
Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
Authors: Patel Et al.
Proc Natl Acad Sci U S A 2016;36:607
Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.
Authors: Weston Et al.
Front Mol Neurosci 2014;7:1
Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.
Authors: Carver Et al.
J Neurosci 2014;34:14181
Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.
Authors: Wu Et al.
J Pharmacol Exp Ther 2013;346:146
The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
Authors: Chen Et al.
On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
Authors: Gouet Et al.
PLoS One 2012;7:e49293
Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission.
Authors: Weston Et al.
J Neurosci 2012;32:11441
Suppression of PKR promotes network excitability and enhanced cognition by IF.-γ-mediated disinhibition.
Authors: Zhu Et al.
Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network.
Authors: Shinoda Et al.
Eur J Neurosci 2011;108:373
Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons.
Authors: Jones Et al.
Int J Neuropsychopharmacol 2011;105:1984
Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor.
Authors: Young and Neher
J Neurosci 2009;63:482
Two distinct types of inhibition mediated by cartwheel cells in the dorsal cochlear nucleus.
J Neurophysiol 2009;102:1287
Synaptic inputs to retinal ganglion cells that set the circadian clock.
Authors: Perez-Leon Et al.
J Neurophysiol 2006;24:1117
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