Chemical Name: 5-Nitro-2-(3-phenylpropylamino)benzoic acid
Biological ActivityInhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of NPPB (5-nitro-1-(3-phenylpropylamino)benzoic acid on chloride transport in intestinal tissues and the T84 cell line.
Keeling et al.
Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein.
Kirkup et al.
5-nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist
Taniguchi et al.
Cl--channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship.
Wangemann et al.
Pflugers Arch., 1986;407:S128
Citations for NPPB
The citations listed below are publications that use Tocris products. Selected citations for NPPB include:
10 Citations: Showing 1 - 10
Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Authors: Rastogi Et al.
PLoS Pathog 2021;17:e1009712
Extracellular fluid flow and chloride content modulate H(+) transport by osteoclasts.
Cell Death Dis 2015;16:20
Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
Authors: Harper and Poole
J Membr Biol 2013;4:e969
Ionic currents of human trabecular meshwork cells from control and glaucoma subjects.
Authors: Grant Et al.
Biol Proced Online 2013;246:167
Lubiprostone reverses the inhibitory action of mor. on mucosal secretion in human small intestine.
Authors: Sun Et al.
Dig Dis Sci 2011;56:330
Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells.
Authors: Sagheddu Et al.
J Physiol 2010;588:4189
Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon.
Authors: Fei Et al.
Am J Physiol Gastrointest Liver Physiol 2009;296:G823
Probenecid, a gout remedy, inhibits pannexin 1 channels.
Authors: Silverman Et al.
Am J Physiol Cell Physiol 2008;295:C761
Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin.
Authors: Li Et al.
Antimicrob Agents Chemother 2005;49:388
Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis.
Authors: Fioretti Et al.
Am J Physiol Cell Physiol 2005;289:C89
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