Catalog # Availability Size / Price Qty
NPPB | CAS No. 107254-86-4 | Calcium-activated Chloride Channel Blockers
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Description: Inhibits calcium-sensitive chloride currents

Chemical Name: 5-Nitro-2-(3-phenylpropylamino)benzoic acid

Purity: ≥99%

Product Details
Citations (10)
Supplemental Products

Biological Activity

Inhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NPPB

The citations listed below are publications that use Tocris products. Selected citations for NPPB include:

10 Citations: Showing 1 - 10

  1. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
    Authors: Rastogi Et al.
    PLoS Pathog  2021;17:e1009712
  2. Extracellular fluid flow and chloride content modulate H(+) transport by osteoclasts.
    Authors: Morethson
    Cell Death Dis  2015;16:20
  3. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
    Authors: Harper and Poole
    J Membr Biol  2013;4:e969
  4. Ionic currents of human trabecular meshwork cells from control and glaucoma subjects.
    Authors: Grant Et al.
    Biol Proced Online  2013;246:167
  5. Lubiprostone reverses the inhibitory action of mor. on mucosal secretion in human small intestine.
    Authors: Sun Et al.
    Dig Dis Sci  2011;56:330
  6. Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells.
    Authors: Sagheddu Et al.
    J Physiol  2010;588:4189
  7. Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon.
    Authors: Fei Et al.
    Am J Physiol Gastrointest Liver Physiol  2009;296:G823
  8. Probenecid, a gout remedy, inhibits pannexin 1 channels.
    Authors: Silverman Et al.
    Am J Physiol Cell Physiol  2008;295:C761
  9. Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin.
    Authors: Li Et al.
    Antimicrob Agents Chemother  2005;49:388
  10. Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis.
    Authors: Fioretti Et al.
    Am J Physiol Cell Physiol  2005;289:C89


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