hh NPPB (CAS 107254-86-4): R&D Systems
Catalog Number: 0593
Chemical Name: 5-Nitro-2-(3-phenylpropylamino)benzoic acid
Biological Activity
Inhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of NPPB (5-nitro-1-(3-phenylpropylamino)benzoic acid on chloride transport in intestinal tissues and the T84 cell line.
    Keeling et al.
    Biochim.Biophys.Acta, 1991;115:42
  2. Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein.
    Kirkup et al.
    Br.J.Pharmacol., 1996;117:175
  3. Cl--channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship.
    Wangemann et al.
    Pflugers Arch., 1986;407:S128
  4. 5-nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist
    Taniguchi et al.
    Pharmacology, 2008;82:245

The citations listed below are publications that use Tocris products. Selected citations for NPPB include:

5 Citations: Showing 1 - 5
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  1. Extracellular fluid flow and chloride content modulate H(+) transport by osteoclasts.
    Authors: Morethson
    Cell Death Dis 2015;16:20
  2. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
    Authors: Harper and Poole
    J Membr Biol 2013;4:e969
  3. Ionic currents of human trabecular meshwork cells from control and glaucoma subjects.
    Authors: Grant Et al.
    Biol Proced Online 2013;246:167
  4. Probenecid, a gout remedy, inhibits pannexin 1 channels.
    Authors: Silverman Et al.
    Am J Physiol Cell Physiol 2008;295:C761
  5. Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin.
    Authors: Li Et al.
    Antimicrob Agents Chemother 2005;49:388

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