Chemical Name: 5-Nitro-2-(3-phenylpropylamino)benzoic acid
Biological ActivityInhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of NPPB (5-nitro-1-(3-phenylpropylamino)benzoic acid on chloride transport in intestinal tissues and the T84 cell line.
Keeling et al.
Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein.
Kirkup et al.
5-nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist
Taniguchi et al.
Cl--channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship.
Wangemann et al.
Pflugers Arch., 1986;407:S128
Citations for NPPB
The citations listed below are publications that use Tocris products. Selected citations for NPPB include:
10 Citations: Showing 1 - 10
Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Authors: Rastogi Et al.
PLoS Pathog 2021;17:e1009712
Extracellular fluid flow and chloride content modulate H(+) transport by osteoclasts.
Cell Death Dis 2015;16:20
Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
Authors: Harper and Poole
J Membr Biol 2013;4:e969
Ionic currents of human trabecular meshwork cells from control and glaucoma subjects.
Authors: Grant Et al.
Biol Proced Online 2013;246:167
Lubiprostone reverses the inhibitory action of mor. on mucosal secretion in human small intestine.
Authors: Sun Et al.
Dig Dis Sci 2011;56:330
Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells.
Authors: Sagheddu Et al.
J Physiol 2010;588:4189
Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon.
Authors: Fei Et al.
Am J Physiol Gastrointest Liver Physiol 2009;296:G823
Probenecid, a gout remedy, inhibits pannexin 1 channels.
Authors: Silverman Et al.
Am J Physiol Cell Physiol 2008;295:C761
Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin.
Authors: Li Et al.
Antimicrob Agents Chemother 2005;49:388
Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis.
Authors: Fioretti Et al.
Am J Physiol Cell Physiol 2005;289:C89
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It blocks calcium-activated chloride currents. We used NPPB at 50-100 microM to block chloride channels. It dissolves well in DMSO