Histamine H1 Receptor Antagonists

Histamine H₁ receptors are G_αq/11-protein-coupled receptors that mediate allergic responses. These receptors are expressed in a wide variety of tissues including the gastrointestinal tract, CNS, airway and vascular smooth muscle cells and endothelial cells.

H₁ receptors are also expressed in chondrocytes, monocytes, neutrophils, dendritic cells, T and B lymphocytes, adrenal medulla, and the cardiovascular and genitourinary systems.

H₁ receptor activation induces a wide range of ...