2 results for "KCC2 Activators" in Products

KCC2 Activators

K+/Cl- cotransporter 2 (KCC2, SLC12A5) is a neuron specific membrane protein that is responsible for the maintenance of the low intracellular Cl- concentration in adult neurons. It is one of four members of the solute carrier 12 (SLC12) family of electroneutral cation-chloride cotransporters and is expressed in most mature mammalian central neurons. KCC2 maintains the intracellular Cl- concentration by using energy from the electrochemical K+ gradient across the plasma membrane to drive Cl- ...

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Selective KCC2 activator

Chemical Name: (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
Purity: ≥98%
Selective KCC2 activator
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K+/Cl- cotransporter 2 (KCC2) activator; orally bioavailable prodrug of CLP 257 (Cat. No.5242)

Chemical Name: (Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate
Purity: ≥98%
K+/Cl- cotransporter 2 (KCC2) activator; orally bioavailable prodrug of CLP 257 (Cat. No.5242)
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