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3 results for "LIMK Inhibitors Small Molecules and Peptides" in Products
LIMK Inhibitors Small Molecules and Peptides
LIM kinases (LIMKs), EC 2.7.11.1, are dual specificity kinases (serine/threonine and tyrosine), which phosphorylate and inactivate cofilin (a key regulator of actin cytoskeleton dynamics). There are two isoforms of LIMK: LIMK1 and LIMK2. LIMKs contain two N-terminal LIM motifs, a PDZ domain, and a C-terminal protein kinase domain.
LIMKs are regulated by the Rho-kinases ROCKI and ROCKII as well as the p21-activated kinases PAK1 and PAK4. Activated LIMKs regulate actin polymerization by ...
| Alternate Names: | BMS 5 |
| Chemical Name: | N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide |
| Purity: | ≥98% |
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| Chemical Name: | N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea |
| Purity: | ≥98% |
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| Chemical Name: | 4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol |
| Purity: | ≥98% |
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