4 results for "mAChR M4 Modulators Small Molecules and Peptides" in Products
mAChR M4 Modulators Small Molecules and Peptides
M4 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gi proteins, generally leading to inhibitory effects. They are one of five muscarinic receptors that act to control the metabotropic functions of acetylcholine in the CNS. M4 receptors are densely populated in the striatum and the lungs.
Activation of the M4 receptor leads to several responses, including the inhibition of adenylyl cyclase. One of the primary roles of M4 receptor activation ...
Positive allosteric modulator of M4 receptors
| Alternate Names: | ML 108 |
| Chemical Name: | 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide |
| Purity: | ≥98% |
Selective positive allosteric modulator of M4 receptors
| Chemical Name: | 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide |
| Purity: | ≥98% |
Positive allosteric modulator of M2 and M4 receptors
| Chemical Name: | 3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide |
| Purity: | ≥98% |
Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic
| Chemical Name: | 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide |
| Purity: | ≥98% |
