p97 ATPase Inhibitors

p97, also known as valosin-containing protein (VCP) in mammals or Cdc48 in yeast, is an ATPase that promotes protein degradation by acting as a protein segregase. It does this by removing proteins from membranous structures, chromatin or protein complexes using the energy generated by ATP hydrolysis.

Ubiquitously expressed in mammals, p97 is primarily localized to the cytoplasm but is also found in the nucleus and associated with the membranes of subcellular organelles. Its main role is to ...