ATPases

ATPases are a group of enzymes that catalyze the hydrolysis of a phosphate bond in adenosine triphosphate (ATP) to form adenosine diphosphate (ADP). They harness the energy released from the breakdown of the phosphate bond and utilize it to perform other cellular reactions. ATPases are essential enzymes in all known forms of life and have fundamental roles in energy conservation, active transport and pH homeostasis.

Targets | Enzyme Data

ATPase Targets

Ca2+-ATPase (Ca2+ -ATPase)

Na+/K+ ATPase (Na+/K+ ATPase)

H+-ATPase (H+-ATPase)

NTPDase (NTPDase)

Kinesin (KIFs)

p97 ATPase (p97 ATPase)

Myosin (Myosin)

 

Related Targets

Cytoskeleton & Motor Proteins

 

Other ATPases

There are three classes of ATPases, which differ in structure and the type of ion that they transport; F-ATPases (e.g. mitochondrial H+-ATPase), P-ATPases (e.g. Ca2+-ATPase, Na+,K+-ATPase) and V-ATPases (e.g. lysosomal H+-ATPase).

Properties of ATPases

TypePFV
Substances TransportedH+, Na+, K+, Ca2+H+ onlyH+ only
Structural and Functional FeaturesLarge catalytic α-subunits become phosphorylated during solute transport. β-subunits regulate transportMultiple TM and cytosolic subunits synthesize ATP on β-subunits, powered by movement of H+ down an electrochemical gradientMultiple TM and cytosolic subunits use energy released from ATP hydrolysis to pump H+ from cytosol to organelle lumen
LocalizationH+ pump: plasma membrane of plants, fungi, bacteria
Na+/K+ pump: plasma membrane of higher eukaryotes
H+/K+ pump: plasma membrane of gastric chief cells
Ca2+ pump: plasma membrane of eukaryotic cells
Ca2+ pump: sarcoplasmic reticulum membrane in muscle cells		Bacterial plasma membranes
Inner mitochondrial membrane
Thylakoid membrane of chloroplast		Vacuolar membranes in plants, yeast and other fungi
Endosomal and lyosomal membranes in eukaryotic cells
Plasma membrane of acid-secreting cells (e.g. osteoclasts)

References

Lodish et al (2000) Molecular Cell Biology. pp590. W.H.Freeman and Company.

Enzyme Data

ATPase Gene Data

GeneSpeciesGene SymbolGene Accession No.Protein Accession No.
ATP1α1HumanATP1A1NM_000701P05023
MouseAtp1a1NM_144900Q8VDN2
RatAtp1a1NM_012504P06685
ATP1α2HumanATP1A2NM_000702P50993
MouseAtp1a2NM_178405Q6PIE5
RatAtp1a2NM_012505O88773
ATP1α3HumanATP1A3NM_152296P13637
MouseAtp1a3NM_144921Q6PIC6
RatAtp1a3NM_012506P06687
ATP1α4HumanATP1A4NM_144699Q13733
MouseAtp1a4TC1638247Q9WV27
RatAtp1a4NM_022848Q64541
ATP1β1HumanATP1B1NM_001001787P05026
MouseAtp1b1NM_009721P14094
RatAtp1b1NM_013113P07340
ATP1β2HumanATP1B2NM_001678P14415
MouseAtp1b2NM_013415P14231
RatAtp1b2NM_012507P13638
ATP1β3HumanATP1B3NM_001679P54709
MouseAtp1b3NM_007502P97370
RatAtp1b3NM_012913Q63377
ATP1β4HumanATP1B4NM_012069Q9UN42
MouseAtp1b4NM_133690Q99ME6
RatAtp1b4NM_053381Q7TPI3
ATP2α1HumanATP2A1NM_004320O14983
MouseAtp2a1NM_007504Q8R429
RatAtp2a1NM_058213Q64578
ATP2α2HumanATP2A2NM_001681P16615
MouseAtp2a2NM_001110140O55143
RatAtp2a2NM_017290P11507
ATP2α3HumanATP2A3NM_174953Q93084
MouseAtp2a3NM_016745Q64518
RatAtp2a3NM_012914P18596
ATP2β1HumanATP2B1NM_001001323P20020
MouseAtp2b1NM_026482NP_080758
RatAtp2b1NM_053311P11505
ATP2β2HumanATP2B2NM_001683Q01814
MouseAtp2b2NM_009723Q9R0K7
RatAtp2b2NM_012508P11506
ATP2β3HumanATP2B3NM_001001344Q16720
MouseAtp2b3NM_177236NP_796210
RatAtp2b3NM_133288Q5EB74
ATP2β4HumanATP2B4NM_001001396P23634
MouseAtp2b4NM_213616NP_998781
RatAtp2b4NM_001005871Q64542
ATP2C1HumanATP2C1NM_001001486P98194
MouseAtp2c1NM_175025Q80XR2
RatAtp2c1NM_131907Q5PQW5
ATP2C2HumanATP2C2NM_014861O75185
MouseAtp2c2NM_026922A7L9Z8
RatAtp2c2NM_134462Q8R4C1
ATP4αHumanATP4ANM_000704P20648
MouseAtp4aNM_018731Q64436
RatAtp4aXM_341834P09626
ATP4βHumanATP4BNM_000705P51164
MouseAtp4bNM_009724P50992
RatAtp4bNM_012510P18598
ATP5α1HumanATP5A1NM_004046P25705
MouseAtp5a1NM_007505Q03265
RatAtp5a1NM_023093P15999
ATP5βHumanATP5BNM_001686P06576
MouseAtp5bNM_016774P56480
RatAtp5bNM_134364P10719
ATP5γ1HumanATP5C1NM_005174P36542
MouseAtp5c1NM_001112738Q91VR2
RatAtp5c1NM_053825P35435
ATP5δHumanATP5DNM_001001975P30049
MouseAtp5dNM_025313Q9D3D9
RatAtp5dNM_139106P35434
ATP5εHumanATP5ENM_001001977P56381
MouseAtp5eNM_025983P56382
RatAtp5eNM_139099P29418
ATP5F1HumanATP5F1NM_001688P24539
MouseAtp5f1NM_009725Q9CQQ7
RatAtp5f1NM_134365P19511
ATP5G1HumanATP5G1NM_001002027P05496
MouseAtp5g1NM_007506P48202
RatAtp5g1NM_017311Q06645
ATP5G2HumanATP5G2NM_001002031Q06055
MouseAtp5g2NM_026468P56383
RatAtp5g2NM_133556Q06646
ATP5G3HumanATP5G3NM_001002258P48201
MouseAtp5g3NM_175015P56384
RatAtp5g3NM_053756Q71S46
ATP5HHumanATP5HNM_006356O75947
MouseAtp5hNM_027862Q9DCX2
RatAtp5hNM_019383P31399
ATP5IHumanATP5INM_007100P56385
MouseAtp5kNM_007507Q06185
RatAtp5iNM_080481P29419
ATP5JHumanATP5JNM_001003696P18859
MouseAtp5jNM_016755P97450
RatAtp5jNM_053602P21571
ATP5LHumanATP5LNM_006476O75964
MouseAtp5lNM_013795Q9CPQ8
RatAtp5lNM_212516Q6PDU7
ATP5OHumanATP5ONM_001697P48047
MouseAtp5oNM_138597Q9DB20
RatAtp5oNM_138883Q06647
ATP5SHumanATP5SNM_015684Q99766
MouseAtp5sNM_026536Q9CRA7
RatAtp5sNM_001007749Q5XIM4
ATP6AP1HumanATP6AP1NM_001183Q15904
MouseAtp6ap1NM_018794Q9R1Q9
RatAtp6ap1NM_031785O54715
ATP6AP2HumanATP6AP2NM_005765Q9UG89
MouseAtp6ap2NM_027439Q9CYN9
RatAtp6ap2XM_217592Q6AXS4
ATP6V1AHumanATP6V1ANM_001690P38606
MouseAtp6v1aNM_007508P50516
RatAtp6v1aNM_001108318NP_001101788
ATP6V1B1HumanATP6V1B1NM_001692P15313
MouseAtp6v1b1NM_134157NP_598918
RatAtp6v1b1NM_001107867XP_232119
ATP6V1B2HumanATP6V1B2NM_001693P21281
MouseAtp6v1b2NM_007509P62814
RatAtp6v1b2NM_057213P62815
ATP6V1C1HumanATP6V1C1NM_001695P21283
MouseAtp6v1c1NM_025494Q9Z1G3
RatAtp6v1c1NM_001011992Q5FVI6
ATP6V1C2HumanATP6V1C2NM_144583Q8NEY4
MouseAtp6v1c2NM_133699Q99L60
RatAtp6v1c2NM_001014199Q6AYE4
ATP6V1DHumanATP6V1DNM_015994Q9Y5K8
MouseAtp6v1dNM_023721P57746
RatAtp6v1dNM_199386Q6P503
ATP6V1E1HumanATP6V1E1NM_001696P36543
MouseAtp6v1e1NM_007510P50518
RatAtp6v1e1NM_198745Q6PCU2
ATP6V1E2HumanATP6V1E2NM_080653Q96A05
MouseAtp6v1e2NM_029121Q9D593
RatAtp6v1e2NM_001108979XP_345633
ATP6V1FHumanATP6V1FNM_004231P06576
MouseAtp6v1fNM_025381Q9D1K2
RatAtp6v1fNM_053884P50408
ATP6V1G1HumanATP6V1G1NM_004888O75348
MouseAtp6v1g1NM_024173Q9CR51
RatAtp6v1g1NM_001106660XP_216411
ATP6V1G2HumanATP6V1G2NM_130463O95670
MouseAtp6v1g2NM_023179Q9WTT4
RatAtp6v1g2NM_212490Q811A7
ATP6V1G3HumanATP6V1G3NM_133326Q96LB4
MouseAtp6v1g3NM_177397Q8BMC1
RatAtp6v1g3NM_001105991XP_213980
ATP6V1HHumanATP6V1HNM_015941Q9UI12
MouseAtp6v1hNM_133826Q8BVE3
RatAtp6v1hNM_001013929Q5XIL1
ATP6V0A1HumanATP6V0A1NM_001130020Q93050
MouseAtp6v0a1NM_016920Q9Z1G4
RatAtp6v0a1NM_031604P25286
ATP6V0A2HumanATP6V0A2NM_012463Q9Y487
MouseAtp6v0a2NM_011596P15920
RatAtp6v0a2NM_053775Q2I6B1
ATP6V0A4HumanATP6V0A4NM_130840Q9HBG4
MouseAtp6v0a4NM_080467Q920R6
RatAtp6v0a4NM_001106591XP_231615
ATP6V0BHumanATP6V0BNM_004047Q99437
MouseAtp6v0bNM_033617Q91V37
RatAtp6v0bNM_001106681XP_216510
ATP6V0CHumanATP6V0CNM_001694P27449
MouseAtp6v0cNM_009729P63082
RatAtp6v0cNM_130823P63081
ATP6V0D1HumanATP6V0D1NM_004691P61421
MouseAtp6v0d1NM_013477P51863
RatAtp6v0d1NM_001011927Q5M7T6
ATP6V0D2HumanATP6V0D2NM_152565Q8N8Y2
MouseAtp6v0d2NM_175406Q80SY3
RatAtp6v0d2NM_001011972Q5FVL0
ATP6V0E1HumanATP6V0E1NM_003945O15342
MouseAtp6v0eNM_025272Q9CQD8
RatAtp6v0e1NM_053578Q794C0
ATP6V0E2HumanATP6V0E2NM_145230Q8NHE4
MouseAtp6v0e2NM_133764Q91XE7
RatAtp6v0e2NM_001002253Q5EB76
ATP7αHumanATP7ANM_000052Q04656
MouseAtp7aNM_001109757Q64430
RatAtp7aNM_052803P70705
ATP7βHumanATP7BNM_000053P35670
MouseAtp7bNM_007511Q64446
RatAtp7bNM_012511Q64535
ATP8A1HumanATP8A1NM_001105529Q9Y2Q0
MouseAtp8a1NM_001038999P70704
RatAtp8a1XM_223390XP_223390
ATP8A2HumanATP8A2NM_016529Q9NTI2
MouseAtp8a2NM_015803P98200
ATP8B1HumanATP8B1NM_005603O43520
MouseAtp8b1NM_001001488NP_001001488
RatAtp8b1NM_001106140XP_214553
ATP8B2HumanATP8B2NM_020452P98198
MouseAtp8b2NM_001081182P98199
RatAtp8b2NM_001024798Q4V8A7
ATP8B3HumanATP8B3NM_138813O60423
MouseAtp8b3NM_026094NP_080370
RatAtp8b3XM_234937XP_234937
ATP8B4HumanATP8B4NM_024837Q8TF62
MouseAtp8b4NM_001080944NP_001074413
RatAtp8b4XM_001055184Q4KLY5
ATP9AHumanATP9ANM_006045O75110
MouseAtp9aNM_015731O70228
RatAtp9aU78977O70128
ATP9BHumanATP9BNM_198531O43861
MouseAtp9bNM_015805P98195
RatAtp9bNM_001106130Q5XFX3
ATP10AHumanATP10ANM_024490O60312
MouseAtp10aNM_009728O54827
RatAtp10aNM_001141935Q32Q02
ATP10BHumanATP10BNM_025153O94823
MouseAtp10bNM_176999NP_795973
RatAtp10bXM_220314XP_220314
ATP10DHumanATP10DNM_020453Q9P241
MouseAtp10dNR_003966Q8K2X1
RatAtp10dXM_341209XP_341210
ATP11AHumanATP11ANM_015205P98196
MouseAtp11aNM_015804P98197
RatAtp11aNM_001107324XP_225014
ATP11BHumanATP11BXM_087254Q9Y2G3
MouseAtp11bNM_029570NP_083846
RatAtp11bXM_342228Q5RJS7
ATP11CHumanATP11CNM_173694Q6ZUP7
MouseAtp11cNM_001037863Q9QZW0
RatAtp11cXR_007360-
ATP12αHumanATP12ANM_001676P54707
MouseAtp12aNM_138652Q9Z1W8
RatAtp12aNM_133517P54708
ATP13A1HumanATP13A1NM_020410Q9HD20
MouseAtp13a1NM_133224Q9EPE9
RatAtp13a1NM_001106079XP_214310
ATP13A2HumanATP13A2NM_022089Q9NQ11
MouseAtp13a2NM_029097Q9CTG6
RatAtp13a2XM_342962XP_342963
ATP13A3HumanATP13A3NM_024524Q9H7F0
MouseAtp13a3NM_001128096Q5XF89
RatAtp13a3XM_001053119XP_001053119
ATP13A4HumanATP13A4NM_032279Q4VNC1
MouseAtp13a4NM_172613Q5XF90
RatAtp13a4XM_221355XP_221355
ATP13A5HumanATP13A5NM_198505Q4VNC0
MouseAtp13a5NM_175650Q3TYU2
RatAtp13a5XM_221354XP_221354
NTPDase 1HumanENTPD1NM_001776S73813
MouseEntpd1NM_009848P55772
RatEntpd1NM_022587P97687
NTPDase 2HumanENTPD2NM_001776S73813
MouseEntpd2NM_009849O55026
RatEntpd2NM_172030O35795
NTPDase 3HumanENTPD3NM_001248O75355
MouseEntpd3NM_009849O55026
RatEntpd3NM_178106Q80Z26