Papain-like Protease Inhibitors Small Molecules and Peptides

Papain-like protease (PLpro) is a 35kDa cysteine protease found in coronaviruses that is important in viral replication. This enzyme is a functional monomer with four structural domains named finger, palm, thumb and ubiquitin-like. The active site is located at the interface of the palm and thumb domains. Sequence modelling suggests the PLpro has 6 transmembrane domains towards the c-terminal, and a long tail that extends into the cytoplasm. Although the structure of the active site is highly ...