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3 results for "PARG Inhibitors Small Molecules and Peptides" in Products
PARG Inhibitors Small Molecules and Peptides
PARG (E.C. 3.2.1.143) is encoded by the PARG gene, which has several transcript variants encoding different isoforms of the enzyme. The PARG gene variants produce proteins of different lengths, which show distinct tissue specificity and subcellular distribution; PARG111 displays nuclear localization and is responsible for degradation of PARP1/2-derived PARylation. PARG102 and PARG99 are found in the cytoplasm and perinuclear regions and regulate PAR-induced cytoplasmic granule production and ...
Potent and selective PARG inhibitor; cell permeable
| Chemical Name: | 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide |
| Purity: | ≥98% |
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Potent PARG inhibitor
| Chemical Name: | 1-[(2,4-Dimethyl-5-thiazolyl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide |
| Purity: | ≥98% |
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High affinity and potent PARG inhibitor
| Chemical Name: | 1-[(2,4-Dimethyl-5-thiazolyl)methyl]-2,3-dihydro-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)-1H-benzimidazole-5-sulfonamide |
| Purity: | ≥98% |
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