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3 results for "PERK Small Molecules and Peptides" in Products
PERK Small Molecules and Peptides
PERK, a type 1 endoplasmic reticulum (ER) membrane kinase, mediates eIF2 alpha phosphorylation at Ser51 during the UPR (unfolded protein response). Protein synthesis is inhibited, thereby reducing the burden of protein substrate for the ER folding and degradation mechanism. Phosphorylation of eIF2 alpha by PERK also selectively promotes the express...
Potent and selective PERK inhibitor; orally bioavailable
| Chemical Name: | 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride |
| Purity: | ≥98% |
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Integrated stress response (ISR) inhibitor
| Chemical Name: | N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] |
| Purity: | ≥98% |
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Potent and selective PERK inhibitor; orally bioavailable
| Chemical Name: | 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone |
| Purity: | ≥98% |
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