PERK: Products

PERK, a type 1 endoplasmic reticulum (ER) membrane kinase, mediates eIF2 alpha phosphorylation at Ser51 during the UPR (unfolded protein response). Protein synthesis is inhibited, thereby reducing the burden of protein substrate for the ER folding and degradation mechanism.

"PERK" has 6 results in Products.
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trans-ISRIB

Integrated stress response (ISR) inhibitor

GSK 2606414

Potent and selective PERK inhibitor; orally bioavailable

AMG PERK 44

Potent and selective PERK inhibitor; orally bioavailable

Azoramide

Unfolded protein response (UPR) modulator

Trazodone hydrochloride

5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant
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