PERK: Products

PERK, a type 1 endoplasmic reticulum (ER) membrane kinase, mediates eIF2 alpha phosphorylation at Ser51 during the UPR (unfolded protein response). Protein synthesis is inhibited, thereby reducing the burden of protein substrate for the ER folding and degradation mechanism.

"PERK" has 6 results in Products.
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trans-ISRIB 

Integrated stress response (ISR) inhibitor

AMG PERK 44 

Potent and selective PERK inhibitor; orally bioavailable

GSK 2606414 

Potent and selective PERK inhibitor; orally bioavailable

Trazodone hydrochloride 

5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant

Azoramide 

Unfolded protein response (UPR) modulator
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