Slit2 Proteins and Enzymes

Slit2 (Slit Homolog 2) is a secreted axon guidance molecule that binds to ROBO-1, -2, -3, and -4, Laminin-1, DAN, Gremlin, and Glypican-1. It regulates axon guidance, initiates axon repulsion, induces growth cone collapse, inhibits oligodendrocyte precursor cell migration, and promotes axon elongation, branch formation, and fasciculation. Proteolytic cleavage of Slit2 generates N- and C-terminal fragments that repel motor axon migration or promote axon migration, respectively. Outside the nervous system, Slit2 plays a role in cell adhesion and migration, tumor progression and metastasis, angiogenesis, lymphangiogenesis, HIV-1 replication, platelet function and thrombus formation, and stem cell senescence.