Somatostatin R3/SSTR3 Small Molecules and Peptides

Somatostatin Receptor 3 (SSTR3) is one of five 7-transmembrane G-protein-coupled receptors for somatostatins 14 and 28. SSTR3 protein has been detected in anterior pituitary, lymphocytes, thyroid, parathyroid, stomach, small intestine, and pancreatic islets. In neurons, it is located within cilia and is implicated in object recognition memory. It is an inhibitory receptor that transduces the antiproliferative and antisecretive effects of somatostatins in the pituitary.