Blogs for June 2018

ISSCR 2018 - Highlighting Stem Cell Therapy and 3-D Modeling

Thursday, June 28, 2018 - 14:43
Another exciting International Society for Stem Cell Research (ISSCR) Annual Meeting has concluded

Another exciting International Society for Stem Cell Research (ISSCR) Annual Meeting has concluded. This year’s meeting, held in Melbourne, Australia (June 19-22nd, 2018), enabled the local stem cell research community to shine with many plenary talks, scientific presentations, and posters provided by researchers from Melbourne Universities and Hospitals. It was impressive! Many stem cell scientists were unable to attend the meeting due to the exotic and remote location. This summary will provide a snapshot of scientific themes and interesting science featured at the meeting.

Stem Cell Therapy

ISSCR 2018 was bookended by two invigorating symposia highlighting...

Advancing the Culture and Clonogenic Analysis of Gastrointestinal Stem Cells

Tuesday, June 19, 2018 - 09:19

In this webinar, Drs. Wa Xian and Frank McKeon, detail their work advancing model systems of the gastrointestinal tract. Specifically, their research focuses on utilizing a powerful system for the isolation, clonogenic culture, and differentiation of adult gastrointestinal stem cells, as described in Wang, X. et al (2015) Nature 522:173. They discuss why their system is vastly more simple and robust than the induced pluripotent stem cell (iPSC) and organoid platforms that presently dominate gastrointestinal research, how it is the only system that enables the dissection of stem cell heterogeneity underlying human disease, and why it is ideal for genome editing, autologous transplantation, large scale pathway analysis, and disease modeling. Their research is...

The Heat Is On: Detecting Chemokine Receptors on Live Cells

Friday, June 15, 2018 - 13:14
CCR7

Chemokine receptors and other multipass proteins require special consideration when staining live cells for flow cytometry analysis. These receptors have seven transmembrane domains, all of which are fluid and moving around in the cell membrane. As a result, the three extracellular loops, to which antibodies must bind, are also moving and this motion can change the orientation of antibody binding sites. While this domain flexibility is necessary for ligand binding to the receptor, it can create problems for flow cytometry staining of live cells. In addition to movement within the lipid membrane, chemokine receptors can undergo internalization and endocytic recycling,...

Bio-Techne Go Everywhere Travel Grant – May 2018 Recipient Selected!

Monday, June 11, 2018 - 10:24
Bio-Techne travel grants

May 2018 Go Everywhere with Bio-Techne Travel Grant Awarded to PhD Student from the University of Padova!

Bio-Techne’s Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.

The recipient of the May 2018 grant is Diana Piol, a PhD Student in the Biomedical Sciences department at the University of Padova in Padova, Italy!

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What Are the AT(N) Biomarkers for Alzheimer’s Disease?

Friday, June 8, 2018 - 10:42
Atlanta Biological Fetal Bovine Serum and Media

Researchers have long been attempting to identify and validate specific biomarkers for Alzheimer’s disease (AD). AD is a neurodegenerative disorder that is characterized by brain atrophy resulting from neuronal loss. It is typically diagnosed following a series of clinical assessments that include neurological and mental examinations and brain imaging. However, since many other disorders also display AD-like symptoms, the only way to definitively diagnosis AD is by tying clinical assessment of the disease to the postmortem identification of its pathological hallmarks (i.e. senile plaques...