Ubiquitin-Related Products

Boston Biochem is now R&D Systems!

Quality Ubiquitin Products From
the Same Team With the Same Expertise





Ubiquitin and Ubiquitin-like Modifiers

Recombinant and natural Ubiquitin proteins, Ubiquitin-like Modifiers and Regulators, mutants, chains, and antibodies

SUMO, NEDD8, FAT10, ISG15, and UFM1

E1 Activating Enzymes

E1 enzymes and inhibitors

E2 Conjugating Enzymes

E2 enzymes and antibodies

E3 Ligases

E3 ligasesinhibitors, and accessory proteins

Affinity Matrices

Affinity matrices

Deubiquitinating/Deconjugating Enzymes

Deubiquitinating/deconjugating enzymes, inhibitors, and antibodies

Heat Shock Proteins

Heat shock proteins, inhibitors, and antibodies

Buffers and Substrates

Buffers and substrates


Proteasome enzymes, inhibitors, and substrates


R&D Systems is your best source for Ubiquitin Proteasome System (UPS) related research products.

With over 20 years’ experience providing high quality recombinant proteins, small molecules, and substrates to the ubiquitin research community, R&D Systems has built the widest available selection of ubiquitin and ubiquitin-related products. We develop and manufacture our proteins using the latest protein expression and purification strategies and pride ourselves on delivering quality proteins that perform as expected.. As the ubiquitin research field evolves and grows, R&D Systems is there to provide you with the best tools to advance your research.

We offer a large range of full-length recombinant deubiquitinases (deubiquitylases, or DUBs) such as USP7 for enzymatic assays and high throughput screening campaigns, and provide the best quality DUB substrates such as Ubiquitin-AMC, Ubiquitin-rhodamine and ISG15-AMC.

If you need help with Targeted Protein Degradation (TPD or PROTACS®) assays, we provide a rapidly expanding portfolio of highly active E3 Ubiquitin Ligases including VHL and Cereblon (CRBN) proteins.  We also provide Cullin-Rbx complexes (including neddylated cullins) that can be coupled to your purified substrate binding complexes to generate active ligases.

Interested in Alzheimer’s, Parkinson’s or ALS research?  We have recombinant Tau proteins, α-Synuclein and TDP-43, as well as the most active USP30 and Parkin (PARK2) enzymes available.

About Us

R&D Systems Ubiquitin-Proteasome Group, formerly known as Boston Biochem, is the leading global producer of ubiquitin-related research products. Since 1997, it has been our mission to provide ubiquitin proteasome system (UPS) researchers with innovative tools that facilitate and accelerate drug discovery efforts. We specialize in providing the highest quality ubiquitin and ubiquitin-like (Ubl) proteins, E1, E2 and E3 Ubiquitin ligases, proteasomes and other UPS-related reagents. Extensive expertise in protein purification, characterization and assay development, as well as a close relationship with the UPS research community, allows us to offer the most comprehensive product range available. The same ubiquitin expertise and quality that you have come to expect from Boston Biochem will continue within R&D Systems. We look forward to hearing from you and learning how we can help advance your research efforts.

Can’t Find Your Protein? Talk to us!

With the sheer number of proteins encompassing the ubiquitin field, we must prioritize which proteins to produce. We may not offer your protein, but it could be in development. Please reach out to our Custom Protein Team to inquire about your protein of interest.

Other Resources

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.