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ROR gamma t and Th17 Cells: New Highly-specific Antibody Will Find What You Have Been Missing

Thursday, July 20, 2017 - 11:22
Antibody Development

Antibody validation and specificity are not new headlines in the research community. Recent comparisons of R&D Systems® Human/Mouse ROR gamma t Recombinant Monoclonal Antibody (Clone # 1181A) to other ROR gamma t clones, demonstrate its superior performance. The data shown below suggest that a popular clone from another supplier is giving false negatives in mouse Th17-differentiated splenocytes and has markedly lower staining of ROR gamma t in human Th17 cells. R&D Systems strives to produce the highest quality...

Bio-Techne Go Everywhere Travel Grant - June Recipient Selected!

Thursday, July 13, 2017 - 09:34
Bio-Techne travel grants

June 2017 Go Everywhere with Bio-Techne Travel Grant Awarded to PhD Student from the Indian Institute of Chemical Biology!

Bio-Techne launched its Go Everywhere Travel Grant Program which awards $1000 USD (or equivalent) to 1 researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.

The recipient of the June 2017 grant is Titli Nargis, a PhD Student at CSIR-Indian Institute of Chemical biology in Kolkata, India!

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Stem Cells in the News - July 2017

Thursday, July 6, 2017 - 13:05
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

Exciting Science & Trends from ISSCR 2017

Thursday, June 29, 2017 - 14:04
Bio-Techne travel grants

It was another exciting year for science at the 2017 International Society for Stem Cell Research (ISSCR) Meeting! Playing on the meeting theme, ‘Science Insightfully Delivered’, there was a palatable emphasis in presentation topics focusing on translating stem cell research to the clinic. The translational aspect was complemented by some great posters and lectures highlighting cutting-edge science being done by the stem cell research community. Here are a couple of scientific hits and themes that we identified from the meeting.

Zika Virus and Brain Model Systems

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Quantikine ELISA Validation: Making the Industry Gold Standard

Thursday, June 22, 2017 - 13:28
Bio-Techne travel grants

When selecting an ELISA kit, different users often have different criteria in making their choice, whether it is sensitivity, sample types, or ease-of-use. One universal criterion is that an ELISA must work the first time and every time you use it. R&D Systems has developed our
Quantikine® ELISAs from raw materials that we make in-house, giving us unparalleled control over critical elements that affect your results and creating consistency of results over long periods of time. Whether you are breaking new ground or building on the work of others, you can trust that the results will be reproducible tomorrow, next week, and next year....

All Pluripotent Stem Cells Are Not Created Equal

Monday, June 19, 2017 - 13:08
Not All iPS Cells Are Created Equal

The generation of induced pluripotent stem (iPS) cells has become a routine task in many laboratories. Across the globe, scientists are using published or commercial reprogramming methods to create iPS cells that further their studies in regenerative medicine, disease modeling, and drug discovery. As we noted in a previous blog post, questions about experimental reproducibility are percolating to the top of major issues that the stem cell field must address in order to confidently guide basic...

Bio-Techne Go Everywhere Travel Grant – May Recipient Selected!

Monday, June 12, 2017 - 10:47
Bio-Techne travel grants

May 2017 Go Everywhere with Bio-Techne Travel Grant Awarded to PhD Candidate from Griffith Institute for Drug Discovery!

Bio-Techne launched its Go Everywhere Travel Grant Program which awards $1000 USD (or equivalent) to 1 researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.

The recipient of the May 2017 grant is Hannah Leeson, a PhD Candidate at Griffith University in Nathan, Australia!

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Butyrophilins, Cancer, and Inflammation

Tuesday, June 6, 2017 - 07:06
Butyrophilins Cancer and Inflammation
 
T cell activation requires two signals: 1) recognition of the antigenic peptide/major histocompatibility complex (MHC) by the T cell receptor (TCR) and 2) antigen-independent co-stimulation induced by interactions between co-signaling molecules expressed on antigen-presenting cells (APCs) and their T cell-expressed receptors.
b7 family proteins
 

The butyrophilins are closely...

Next Generation Targets for Immuno-Oncology

Tuesday, June 6, 2017 - 05:59
R&D Systems Immuno-Oncology Webinar with Anthony Person, PhD

Anthony Person, PhD, Manager in Bioassay Development at Bio-Techne
Scott Schachtele, PhD, Product Manager at Bio-Techne

Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family members, novel immunoregulatory pathways are being uncovered as potential targets for oncology research and cancer immunotherapy. In this presentation, we discuss some of the next generation of novel immune checkpoint molecules, including Butyrophilins (BTNs), leukocyte...

Stem Cells in the News - June 2017

Monday, June 5, 2017 - 10:46
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

SMER28 and iPSCs Pave Possible New Treatment Option for Anemic Patients – Harvard News
Researchers from Boston Children’s Hospital have, for the first time, used patient-derived iPSCs to create red blood cells in humans with Diamond-Blackfan Anemia (DBA). DBA patients lack the erythroid cells needed to generate mature red blood cells. The team of researchers, which includes George Q. Daley and Leonard Zon, performed a chemical screening of...

Actual Living Scientist – Rachel Weller Roska

Monday, June 5, 2017 - 09:22
Rachel Weller Roska of Bio-Techne

It recently came to our attention, from this article, that only one in three Americans can name an actual living scientist. As a large biotechnology company, filled with talented and dedicated scientists, we think that is ridiculous. We want to introduce you to some of our staff who are, in fact, Actual Living Scientists.

The next scientist in our series is Rachel Weller Roska. Rachel has been with Bio-Techne for 5 years at the R&D Systems site (and Bio-Techne Headquarters) in Minneapolis, MN. Rachel works in our Proteome Profiler Array Development Department as a Scientist...

Actual Living Scientist – Martin Ramsden

Tuesday, May 30, 2017 - 10:10
Martin Ramsden, Commercial Development Manager

It recently came to our attention, from this article, that only one in three Americans can name an actual living scientist. As a large biotechnology company, filled with talented and dedicated scientists, we think that is ridiculous. We want to introduce you to some of our staff who are, in fact, Actual Living Scientists.

The next scientist in our series is Martin Ramsden, PhD. Martin has been with Bio-Techne for 8 years at the R&D Systems site (and Bio-Techne Headquarters) in Minneapolis, MN. Martin works in our Commerical Development Department, which develops...

New Scientific Poster Presented AAI 2017

Thursday, May 25, 2017 - 10:01
M1 and M2a Macrophage Phenotypic Characterization Poster
 

Bio-Techne scientists presented a poster at AAI 2017 demonstrating the effects that cell culture conditions can have on the phenotypic characterization of human M1 and M2a macrophages. This poster compared the expression of fifty macrophage cell surface markers, leading to the identification of twenty markers that were affected by culturing in the presence of fetal bovine serum (FBS), human serum, or StemXVivo® Serum-Free Dendritic Cell Base Media. Each condition was performed with and without polarizing stimuli.

Download the poster to learn more about the...

Actual Living Scientist – Kristin Jacobsen

Monday, May 22, 2017 - 11:37
Kristin Jacobsen

It recently came to our attention, from this article, that only one in three Americans can name an actual living scientist. As a large biotechnology company, filled with talented and dedicated scientists, we think that is ridiculous. We want to introduce you to some of our staff who are, in fact, Actual Living Scientists.

The next scientist in our series is Kristin Jacobsen. Kristin just celebrated 6 years with Bio-Techne at the R&D Systems site (and Bio-Techne Headquarters) in Minneapolis, MN. Kristin not only works in Protein Development, she also recently completed her MBA at the University of...

Introducing Our Quarterly Protein Update!

Monday, May 22, 2017 - 11:21
Protein Structure Banner
 
Anthony Person, Ph.D.
Next Generation Targets for Immuno-Oncology!
On May 4th Bio-Techne hosted a webinar on Next Generation Targets for Immunotherapy. Bio-Techne scientist, Anthony Person, Ph.D., discussed novel immunoregulatory pathways that the R&D Systems protein group has uncovered as potential targets for cancer immunotherapy. Watch now!
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Post AACR Blog #2: Cancer Immunotherapy

Tuesday, May 16, 2017 - 12:08
Bio-Techne Bubble

The ability to mobilize the immune system to fight cancer has revolutionized the way we treat this disease. It’s no surprise that Cancer Immunotherapy was a prominent topic at the 2017 American Association for Cancer Research (AACR) annual meeting. Despite the successes associated with immunotherapy there are still many questions to be answered. Investigators at AACR provided a nice framework for future research by posing both big picture and mechanistic questions. Why does immunotherapy work only for a small percentage of patients? What are the mechanisms of cancer resistance and how can we overcome them? What role does the tumor microenvironment play? What model system is most appropriate for preclinical studies? What about combination therapy? How do you evaluate the utility...

Actual Living Scientist – Kylie Bruner

Monday, May 15, 2017 - 09:35
Kylie Bruner

It recently came to our attention, from this article, that only one in three Americans can name an actual living scientist. As a large biotechnology company, filled with talented and dedicated scientists, we think that is ridiculous. We want to introduce you to some of our staff who are, in fact, Actual Living Scientists.

The next scientist in our series is Kylie Bruner. Kylie has been with Bio-Techne for just under 1 year at the R&D Systems site (and Bio-Techne Headquarters) in Minneapolis, MN. Kylie works in our Proteins Purification Department, which is the starting point for many of the high quality...

Neuroscience Research Review: Stanford Team Finds A1 Astrocytes are Induced by Activated Microglia

Friday, May 12, 2017 - 07:45
Activated Microglia Induce the Formation of A1 Astrocytes

Astrocytes are the most numerous glia cells in the central nervous system (CNS). They help to maintain the health and function of the CNS, by providing metabolic support to neurons, clearing neurotransmitters from synapses, supporting blood-brain barrier endothelial cells, regulating extracellular ion concentrations, forming and maturating synapses, and modulating synaptic plasticity. Astrocytes have also been implicated in neurodegenerative diseases. CNS injury and disease induce astrocytes to undergo reactive astrogliosis, which involves both biochemical and structural changes to astrocytes. Previous studies from the lab of Dr. Ben Barres at Stanford University School of Medicine characterized two different types...

Bio-Techne Go Everywhere Travel Grant – April Recipient Selected!

Wednesday, May 10, 2017 - 15:03
Bio-Techne travel grants

April 2017 Go Everywhere with Bio-Techne Travel Grant Awarded to PhD Candidate at The University of Bonn!

Bio-Techne launched its Go Everywhere Travel Grant Program which awards $1000 USD (or equivalent) to 1 researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.

The recipient of the April 2017 grant is Janine Groß, a PhD Candidate at the University of Bonn!

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Stem Cells in the News – May 2017

Wednesday, May 10, 2017 - 14:06
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

Sparking Faster MSC Differentiation into Schwann-Like Cells - Iowa State University
Researchers at Iowa State University have developed a nanotechnology that uses a 3-D Nanostructure and circuit boards that stimulates the differentiation of Mesenchymal Stem Cells (MSCs) into Schwann-like cells. Their technology could be the solution to an otherwise long and expensive process by which MSCs are pushed to a Schwann-like fate and could hold promise in accelerating studies looking to promote...

AACR Recap #1: New Biomarker Candidates!

Monday, May 8, 2017 - 13:30
Cancer biomarkers

Most investigators agree that early detection increases the likelihood of a positive response to a given therapeutic intervention in cancer. Biomarkers are a necessary prerequisite for early detection. A healthcare provider needs some clue that cancer is likely to develop. More importantly, they need to know that the selected therapeutic intervention will be effective. It is no surprise then, that much of the work presented at the 2017 American Association for Cancer Research (AACR) was focused on discovering and validating novel cancer biomarkers.

Mahoney and Atkins describe four types of cancer biomarkers: diagnostic,...

Actual Living Scientist – Dr. Louis Leong

Monday, May 8, 2017 - 08:33
Dr. Louis Leong of Bio-Techne

It recently came to our attention, from this article, that only one in three Americans can name an actual living scientist. As a large biotechnology company, filled with talented and dedicated scientists, we think that is ridiculous. We want to introduce you to some of our staff who are, in fact, Actual Living Scientists.

The first scientist in our series is Dr. Louis Leong. Dr. Leong has been with Bio-Techne at the R&D Systems site (and Bio-Techne Headquarters) in Minneapolis, MN for 5 years. Dr. Leong completed a Post Doc at UC-Irvine in 2000 before moving into industry at...

Travel Grant Recipients to ISSCR 2017 Announced

Thursday, April 20, 2017 - 13:27
isscr travel grant winners
 

The International Society of Stem Cell Research Annual Meeting is the largest scientific conference focusing on stem cell research. This year, scientists from around the world will gather in Boston, MA from...

Emerging Targets for Cancer Immunotherapy Research

Tuesday, April 18, 2017 - 09:27
Emerging Targets for Cancer Immunotherapy Research

The most successful strategies for cancer immunotherapy have focused on targeting the T cell co-stimulatory and co-inhibitory molecules that regulate T cell activation. Monoclonal antibodies directed against the T cell co-inhibitory receptors, CTLA-4 and PD-1 have been shown to have potent anti-tumor effects, suggesting that other immune checkpoint regulators may also serve as immunotherapeutic targets. CTLA-4 and PD-1 are members of the CD28 family and they each bind...

Good Manufacturing Practice (GMP) for Cell Therapy Manufacturing: What does this mean?

Friday, April 14, 2017 - 14:29
gmp cytokines and growth factor use in cell therapy process

 

Several suppliers, including R&D Systems, offer growth factors and cytokines made specifically for culturing cells that will be used for cell therapy. They are only to be used during the cell culture process and residual protein is washed away before the cells actually come into contact with a patient. These reagents are commonly referred to as GMP (Good Manufacturing Practice), a term that has traditionally been reserved for materials made with oversite from federal regulatory authorities like the FDA. Despite the...

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