Ubiquitin, Related Modifiers, & Pathways

Ubiquitin is a highly conserved globular 76-residue eukaryotic protein found in the cytoplasm and nucleus of cells. Ubiquitin can be covalently attached (conjugated) to proteins in a process termed ubiquitination. This process affects protein stability, subcellular localization, and ability to interact with other proteins. Ubiquitination is now known to be involved in the regulation of a majority, if not all, cellular processes, signaling pathways, and disease states.