Blogs for September 2019

Immunology News: Researchers Identify NR4A and TOX Transcription Factors As Mediators of CD8+ T Cell Exhaustion – Implications for Cancer Immunotherapy

Friday, September 20, 2019 - 13:21

Exhausted CD8<sup>+</sup> T Cell

CD8+ T cell exhaustion or dysfunction is frequently observed in chronic viral infections and cancer due to persistent antigen exposure and chronic T cell receptor (TCR) signaling. The exhausted T cell state is associated with a decrease in proliferative capacity, reduced effector functions, changes in gene expression and metabolism, and elevated and sustained expression of multiple inhibitory receptors, including PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and 2B4/CD244. Under steady state conditions, these inhibitory...

Relax and Go with the Flow: Demystifying Multi-Parameter Flow Cytometry

Tuesday, September 17, 2019 - 08:52

Flow cytometry is a powerful technique that allows researchers to examine multiple proteins on cell populations using fluorescently labeled antibodies. Multi-parameter, fluidic-based flow cytometry has been applied to multiple fields of study ranging from basic to clinical immunology, cancer biology, neuroscience, stem cell research, and drug discovery. In order to maximize the quality of results obtained using this technology, researchers should be familiar with the basics of flow cytometry when setting up an experiment. In this series of seminars, we will discuss the necessary tools to design, run, and analyze a multi-parameter flow cytometric experiment.

Webinar 1 - Relax and Go with the Flow: Demystifying Multi-Parameter Flow Cytometry

In this introductory level webinar, you will learn the basics of how flow cytometry...

Turning Flow Cytometry Upside Down and Inside Out: Cellular Function Revealed

Tuesday, September 17, 2019 - 07:58

Flow cytometry is a powerful technique that allows researchers to examine multiple proteins on cell populations using fluorescently labeled antibodies. Multi-parameter, fluidic-based flow cytometry has been applied to multiple fields of study ranging from basic to clinical immunology, cancer biology, neuroscience, stem cell research, and drug discovery. In order to maximize the quality of results obtained using this technology, researchers should be familiar with the basics of flow cytometry when setting up an experiment. In this series of seminars, we will discuss the necessary tools to design, run, and analyze a multi-parameter flow cytometric experiment.

Webinar 2 - Turning Flow Cytometry Upside Down and Inside Out: Cellular Function Revealed

In this webinar, you will learn how to apply basic concepts of flow cytometry to...