ApoE4 Antibody (4E4) [Janelia Fluor® 525]

Novus Biologicals | Catalog # NBP1-49529JF525

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation

Label

Janelia Fluor 525

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 4E4
View all ApoE4 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide made to an internal region of human ApoE4 (within residues 100-150) [Uniprot: P02649]

Specificity

This antibody is specific for ApoE4. It does not cross-react with the ApoE2 or ApoE3 isoforms.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for ApoE4 Antibody (4E4) [Janelia Fluor® 525]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: ApoE4

Apolipoprotein E (APOE) is an apolipoprotein located in chylomicrons and intermediate-density lipoproteins that is necessary for the normal catabolism of triglyceride-rich lipoprotein constituents in the liver. APOE has recently been shown to be involseveral biological processes other than lipoprotein transport, including cognition and immunoregulation.

Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are essential for the normal breakdown of these molecules. In particular, apolipoprotein E is a major component of very low-density lipoproteins (VLDL), which remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular diseases, including heart attacks and strokes.

There are three known Apo E isoforms (ApoE2, E3 and E4), which are strongly associated with cardiovascular disease and/orAlzheimer's disease. Therefore, ApoE antibodies have become useful tools for research in both of these areas.

Long Name

Apolipoprotein E4

Alternate Names

Apo-E, apolipoprotein E, apolipoprotein E3, late onset), LDLCQ5, MGC1571

Gene Symbol

APOE

Additional ApoE4 Products

Product Documents for ApoE4 Antibody (4E4) [Janelia Fluor® 525]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for ApoE4 Antibody (4E4) [Janelia Fluor® 525]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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