Axl Antibody [ADC] - (Enapotamab Vedotin, Research Grade)

Novus Biologicals | Catalog # NBP3-44503

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

ADC

Antibody Source

Monoclonal Human IgG1
View all Axl Primary Antibodies »

Product Specifications

Immunogen

Axl (Uniprot: P30530)

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Theoretical MW

150.63 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

This product is an Antibody-Drug Conjugate (ADC) for Research Use Only (RUO).

Enapotamab vedotin (previously referred to as HuMax-AXL-ADC or AXL-107-MMAE) is a clinical-stage AXL-specific antibody-drug conjugate that was generated by conjugating a human AXL-specific IgG1 with the microtubule-disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable

Scientific Data Images for Axl Antibody [ADC] - (Enapotamab Vedotin, Research Grade)

Hu Axl mAb [ADC] - (Enapotamab Vedotin)

Flow Cytometry: Hu Axl mAb [ADC] - (Enapotamab Vedotin) [NBP3-44503]

Human Axl HEK293 Cell Line were stained with Axl and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.16 ug/mL.

Applications for Axl Antibody [ADC] - (Enapotamab Vedotin, Research Grade)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectra Viewer
Spectra Viewer

Flow Cytometry Panel Builder

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Save time and reduce costly mistakes by quickly finding compatible reagents using the Panel Builder Tool.

Advanced Features

  • Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
  • Spillover Popups - Visualize the spectra of individual fluorochromes
  • Antigen Density Selector - Match fluorochrome brightness with antigen density
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Flow Cytometry

Formulation, Preparation, and Storage

Purification

>95%, by HPLC

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Axl

Axl is encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.

Long Name

Axl Receptor Tyrosine Kinase

Alternate Names

AI323647, ARK, JTK11, Tyro7, UFO

Additional Axl Products

Product Documents for Axl Antibody [ADC] - (Enapotamab Vedotin, Research Grade)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Axl Antibody [ADC] - (Enapotamab Vedotin, Research Grade)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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