Bestrophin 1 Antibody - BSA Free

Novus Biologicals | Catalog # NBP2-56225

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Bestrophin 1 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: SQVRRKTVEFNLTDMPEIPENHLKEPLEQSPTNIHTTLKDHMDPYWALENRSVLHLNQGHCIALCPTPASLALSLPFLHNFLGFHHCQSTLDLRPALAWGIYLATFTGILGKCSGPFLTSPWYHPEDFLGPGE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Bestrophin 1 Antibody - BSA Free

Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225]

Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225]

Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] - Staining of human retina shows strong membranous positivity in retinal pigment epithelium.
Bestrophin 1 Antibody

Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -

Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -Staining of human skeletal muscle shows no positivity in myocytes as expected.
Bestrophin 1 Antibody

Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -

Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
Bestrophin 1 Antibody

Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -

Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -Staining of human liver shows no positivity in hepatocytes as expected.

Applications for Bestrophin 1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Bestrophin 1

Bestrophin 1 (BEST1) is a member of the bestrophin family of anion channels. Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. Bestrophins are believed to function as chloride channels.

Bestrophin-1, also known as best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an inherited autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). Bestrophin 1 is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin 1's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin-1 is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.

Bestrophin antibodies are useful tools for studies involving vision and retinal disease. .

Alternate Names

ARB, BEST, Best disease, bestrophin 1, bestrophin-1, BMD, TU15B, vitelliform macular dystrophy 2, Vitelliform macular dystrophy protein 2, VMD2RP50

Gene Symbol

BEST1

Additional Bestrophin 1 Products

Product Documents for Bestrophin 1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Bestrophin 1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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