Claudin-18.2 Antibody (DBRRM1.82)

Name: Claudin-18.2 Antibody (DBRRM1.82)
Brand: Novus Biologicals
SKU: NBP3-45116
Price: 169 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-45116

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Kappa Clone # DBRRM1.82

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Product Specifications

Immunogen

Recombinant human Claudin18.2protein fragment (around aa 1-100)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Scientific Data Images for Claudin-18.2 Antibody (DBRRM1.82)

Immunohistochemistry-Paraffin: Rabbit Claudin-18.2 mAb (DBRRM1.82) [NBP3-45116]

Formalin fixed paraffin embedded human gastric carcinoma tissue stained with Claudin18.2.

Applications for Claudin-18.2 Antibody (DBRRM1.82)

Application

Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4), Tween-20, 0.2% BSA

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Claudin-18.2

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternate Names

claudin-18, SFTA5, SFTPJ, surfactant associated 5, surfactant associated protein J, surfactant, pulmonary associated protein J

Gene Symbol

CLDN18

Additional Claudin-18.2 Products

Product Documents for Claudin-18.2 Antibody (DBRRM1.82)

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Certificate of Analysis

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Product Specific Notices for Claudin-18.2 Antibody (DBRRM1.82)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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