FK 866 hydrochloride

Tocris Bioscience | Catalog # 4808

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
Tocris Bioscience
Discontinued Product
4808 has been discontinued. An alternative/replacement product is available: 8072. View all NAMPT Inhibitors products.

Key Product Details

Description

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
View all NAMPT Inhibitors »

Product Description

FK 866 hydrochloride is a non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251).

Product Specifications for FK 866 hydrochloride

Molecular Weight

427.97

Formula

C24H29N3O2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride

CAS Number

2727965-45-7

PubChem ID

78243733

InChI Key

MULSIBUGDPOSHV-CALJPSDSSA-N

SMILES

O=C(C2=CC=CC=C2)N1CCC(CCCCNC(/C=C/C3=CN=CC=C3)=O)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.14 5 with gentle warming
DMSO 42.8 100

Preparing Stock Solutions for FK 866 hydrochloride

The following data is based on the product molecular weight 427.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.68 mL 23.37 mL
5 mM 0.47 mL 2.34 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for FK 866 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FK 866 hydrochloride

For research use only

Citations for FK 866 hydrochloride

Customer Reviews for FK 866 hydrochloride (1)

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  • NAD inhibitor
    Name: Kishor Pant
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Cancer and liver cell lines
    Verified Customer | Posted 04/07/2022
    Inhibition of NAD in cancer cells requires 3-4 days of treatment
    FK866 Inhibits NAD+ production and NAMPT activity in cancer cells.
    FK 866 hydrochloride 4808

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