FK 866

Tocris Bioscience | Catalog # 8072

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
Tocris Bioscience

Key Product Details

Description

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
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Product Description

FK 866 is a non-competitive and high-affinity inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by Etoposide (Cat. No. 1226) and Cisplatin (Cat. No. 2251).

Product Specifications for FK 866

Molecular Weight

391.51

Formula

C24H29N3O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide

CAS Number

658084-64-1

PubChem ID

6914657

InChI Key

KPBNHDGDUADAGP-VAWYXSNFSA-N

SMILES

C(=O)(N1CCC(CCCCNC(/C=C/C=2C=CC=NC2)=O)CC1)C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.15 100
Ethanol 39.15 100

Preparing Stock Solutions for FK 866

The following data is based on the product molecular weight 391.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Product Documents for FK 866

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FK 866

For research use only

Customer Reviews for FK 866 (1)

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  • FK 866
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: RBE and HepG2
    Verified Customer | Posted 12/19/2023
    Treat this drug for 72 hours for best results.
    I used FK 866 in 10–50 nM concentrations for 24-72 hours and noted significant differences in cellular NAD level and cell growth.
    FK 866 8072

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