Human 17 beta-HSD14/HSD17B14 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB7515R Datasheet / COA / SDS

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FAB7515R-100UG

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Human 17 beta-HSD14/HSD17B14 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human 17 beta ‑HSD14/HSD17B14 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 736043

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human 17Î²â€‘HSD14/HSD17B14
Ala2-Ser270
Accession # Q9BPX1

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: 17 beta-HSD14/HSD17B14

HSD-17b14 (hydroxysteroid (17-beta) dehydrogenase type14), also called 17bHSD14 or DHRS10, is a cytoplasmic 17beta-hydroxysteroid dehydrogenase that is a member of the SDR (short-chain dehydrogenase/reductase) family. It is a 270 amino acid, approximately 30 kDa protein with mRNA highly expressed in brain, placenta, liver and kidney. It converts estradiol to estrone, thus inactivating it, and is thought to regulate activity of estrogens and possibly dihydroepiandrosterone (DHEA) in the placenta and central nervous system. Human HSD-17b14 shares 80.5% amino acid sequence identity with mouse and rat HSD-17b14.

Long Name

17 beta Hydroxysteroid Dehydrogenase 14

Entrez Gene IDs

51171 (Human); 66065 (Mouse); 691018 (Rat)

Alternate Names

17 betaHSD14; 17 beta-HSD14; dehydrogenase/reductase (SDR family) member 10; Dehydrogenase/reductase SDR family member 10; DHRS10; DHRS1017-beta-hydroxysteroid dehydrogenase 14; EC 1.1.1.-; HSD17B14; hydroxysteroid (17-beta) dehydrogenase 14,17-beta-hydroxysteroid dehydrogenase DHRS10; retinal short-chain dehydrogenase/reductase 3; Retinal short-chain dehydrogenase/reductase retSDR3; retSDR3; RETSDR3,17-beta-HSD 14; SDR3; SDR47C1; short chain dehydrogenase/reductase family 47C, member 1