Human Annexin A3 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB4855U Datasheet / COA / SDS

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FAB4855U-100UG

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All Annexin A3 Antibodies

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Human Annexin A3 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Annexin A3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human Annexin A1, A2, A4, A6, A8, A9, A10, A11, or A13 is observed.

Source

Monoclonal Mouse IgG2b Clone # 693510

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Annexin A3
Ala2-Asp323
Accession # P12429

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Annexin A3

Annexin A3 (ANXA3), also known as Annexin III and Lipocortin III (LPC3), is a 36 kDa member of the Annexin family of calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexins consist of a unique amino terminal domain followed by a homologous C-terminal core domain containing calcium-dependent phospholipid-binding sites. The C-terminal domain is comprised of four 60-70 amino acid (aa) annexin repeats. Annexin A3 is upregulated in microglia following stroke and in parenchymal hepatocytes in regenerating liver. It can be up- or down‑regulated in various carcinomas. Alternate splicing generates an additional isoform with a 30 amino acid (aa) deletion near the N-terminus. Human Annexin A3 shares 89% and 85% aa sequence identity with mouse and rat Annexin A3, respectively.

Entrez Gene IDs

306 (Human); 11745 (Mouse); 25291 (Rat)

Alternate Names

35-alpha calcimedin; Annexin A3; annexin A3,1,2-cyclic-inositol-phosphate phosphodiesterase; Annexin III; annexin-3; ANXA3; Calcimedin 35-alpha ; calcimedin 35-alpha; Lipocortin III; PAP-III; Placental anticoagulant protein III; placental anticoagulant protein III, calcimedin 35-alpha